Obesity Causes and Consequences (X4)
February 4-7, 2024
| Fairmont Hotel Vancouver, Vancouver, BC, Canada
Giles S.H. Yeo, Karine Clément and Murielle M. Véniant-Ellison
Scholarship Deadline: Oct. 31, 2023 | Abstract Deadline: Oct. 31, 2023 | Early Registration Deadline: Dec. 5, 2023
| 4:00–8:00 PM |
Arrival and Registration |
British Columbia Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
British Columbia Foyer |
| 7:00–8:00 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:00–9:30 AM |
Welcome and Keynote Session (Joint) |
Columbia Ballroom |
| |
* Giles S.H. Yeo, University of Cambridge
Session Chair |
|
| |
* Ewan Pearson, University of Dundee
Session Chair |
|
| |
Stephen O'Rahilly, University of Cambridge
Leveraging Genetics to Understand Metabolic Disease |
|
| |
Jose C. Florez, Massachusetts General Hospital
Optimizing Precision Medicine Across Diverse Ethnicities |
|
| 9:30–9:50 AM |
Coffee Break |
British Columbia Foyer |
| 9:50–11:15 AM |
Genetics of Obesity (Joint) |
Columbia Ballroom |
| |
* Andrea M. Haqq, University of Alberta
Session Chair |
|
| |
Kaja Wasik, Variant Bio
Metabolic Disease in the Context of Genetic Diversity |
|
| |
Peter R. Shepherd, University of Auckland
Population Specific Precision Medicine for Metabolic Disease |
|
| |
Kathrin Landgraf, Center for Pediatric Research, Hospital for Children and Adolescents, Medical Faculty, University of Leipzig
Short Talk: Short Talk: Ectopic ASIP Expression as a Monogenic cause of Childhood Obesity through Possible Interaction with the MC4R Pathway |
|
| |
Yana Hrytsenko, Beth Israel Deaconess Medical Center, Harvard Medical School
Short Talk: Short Talk: Obstructive Sleep Apnea is Associated with Increased Genetic Risk of Incident Diabetes Mellitus: the Hispanic Community Health Study/Study of Latinos |
|
| 11:15–1:00 PM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 2:30–4:30 PM |
Workshop 1 |
Columbia Ballroom |
| |
* Antje Körner, Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) at Helmholtz Munich and Leipzig University
Session Chair |
|
| |
Rifa T Haque, Monash University
The Intestinal MC4R Promotes Weight Loss by Reducing Caloric Intake and Increasing Energy Expenditure |
|
| |
Chen Liu, University of Texas Southwestern Medical Center
Orthopedia Regulates Mc4r Transcription and Human Obesity Risk |
|
| |
Warren T Yacawych, University of Michigan
Different Roles in Food Intake Regulation for Distinct Populations of Dorsal Vagal Complex Glp1r Neurons |
|
| |
Claudia Anett Doege, Columbia University
Functional Genomics of Human Metabolic Disease at Single Cell Resolution |
|
| |
Misbah Rashid, National Institute of Diabates, Digestive, and Kidney Diseases, National Institutes of Health
Presence of Beta-Arrestin-2 is Required for Melanocortin 4 Receptor-Mediated Metabolic Effects |
|
| |
Jeevotham Senthil Kumar, Oklahoma State University
CTRP6-Mediated Suppression of Macrophage M2 Phenotype: Implications for Obesity-Associated Inflammation |
|
| |
Hannah Swick, McGill / RI-MUHC
Glial Support of Neurovascular Function in Obesity |
|
| 4:30–5:00 PM |
Coffee Available |
British Columbia Foyer |
| 5:00–7:00 PM |
Response to Environment |
Columbia Ballroom |
| |
* Thomas Alexander Lutz, University of Zürich
Session Chair |
|
| |
Harriet Schellekens, University College Cork
Microbiota and Stress |
|
| |
Kevin D. Hall, NIDDK, National Institutes of Health
Ultra-Processed Foods and Obesity |
|
| |
Anna Krook, Karolinska Institutet
Intertissue Communication Following an Exercise Bout in Type 2 Diabetes |
|
| |
Simon Krogh Bredum, Novo Nordisk A/S
Short Talk: Short Talk: Exploring Body Composition and Energy Expenditure Changes After Diet Restriction and Pharmacologically Induced Weight loss in a Göttingen Minipig Model of Obesity |
|
| |
Francois Briand, Physiogenex
Short Talk: Short Talk: Semaglutide and Lanifibranor Differentially Alter MASH and Liver Fibrosis in Diet-induced Obese Hamsters With or Without Free Access to Alcohol |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 7:30–10:00 PM |
Poster Session 1 |
Pacific Ballroom, Vancouver Island Room |
Tuesday, February 6, 2024
| 7:00–8:00 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:00–11:30 AM |
Hypothalamic Dysfunction |
Columbia Ballroom |
| |
* Kevin L. Grove, Novo Nordisk
Session Chair |
|
| |
Giles S.H. Yeo, University of Cambridge
Mapping the Feeding Circuitry of the Human Hypothalamus |
|
| |
Sabrina Diano, Columbia University
Hypothalmic Nutrient Sensing |
|
| |
Lora K. Heisler, Rowett Institute, University of Aberdeen
Hypothalamic Mechanisms of Obesity |
|
| |
Martin G. Myers, Jr., University of Michigan
Hindbrain Circuits that Control Feeding |
|
| |
Michael A. Cowley, Monash University
Targeting Hypothalamic Weight-Loss Circuits |
|
| |
Allison Duensing, University of Michigan
Short Talk: Short Talk: Glp1r-expressing LepRb Neurons of the Dorsomedial Hypothalamic Nucleus Inhibit AgRP Neurons and Suppress Body Weight |
|
| |
Addison Nicole Webster, University of Virginia
Short Talk: Short Talk: Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety |
|
| 9:00–9:20 AM |
Coffee Break |
British Columbia Foyer |
| 11:00–1:00 PM |
Poster Setup |
Pacific Ballroom, Vancouver Island Room |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 11:30–12:00 PM |
Health Equity Forum (Joint) |
Columbia Ballroom |
| |
Kaja Wasik, Variant Bio
Panelist |
|
| |
Peter R. Shepherd, University of Auckland
Panelist |
|
| |
Moneeza Siddiqui, Queen Mary University of London
Panelist |
|
| |
Shivani Misra, Imperial College London
Panelist |
|
| |
Moffat Nyirenda, London School of Hygiene and Tropical Medicine
Panelist |
|
| 1:00–10:00 PM |
Poster Viewing |
Pacific Ballroom, Vancouver Island Room |
| 2:30–4:30 PM |
Workshop 2 |
Columbia Ballroom |
| |
* Siegfried Ussar, Helmholtz Zentrum Muenchen GmbH
Session Chair |
|
| |
Christelle Le Foll, University of Zurich
Astrocyte Lipid Metabolism: How it Shapes your Appetite and Energy Balance |
|
| |
Mary N. Teruel, Weill Cornell Medicine
Disrupted Circadian Glucocorticoid Rhythms and High Fat Diet Drive Obesity through Distinct Mechanisms |
|
| |
John A. Tadross, University of Cambridge
HYPOMAP: A Spatio-cellular Atlas of the Human Hypothalamus |
|
| |
Martijn van de Bunt, Cytoki Pharma
Novel Lipidated Interleukin-22 Reduces Body Weight, Lowers Plasma Glucose, and Improves Cardio-Metabolic Risk Factors in Mice |
|
| |
María Moreno López, INSERM
Unlocking Metabolic Benefits Effects of Sodium-Glucose-Co-Transporter-4 (SGLT4) Inhibition: From Mouse Studies to Clinical Translation |
|
| |
Klara Piletic, Kennedy Institute of Rheumatology, University of Oxford
Adipocyte Autophagy in the Control of Obese Adipose Tissue Inflammation and Remodelling |
|
| |
Joon Ho Moon, Seoul National University
Dissecting Adipose Tissue at Single-Cell Resolution During Metabolic Disease Development |
|
| |
Rea P. Anunciado-Koza, Maine Medical Center Research Institute
Disruption of Mesoderm Specific Transcript (Mest) in Female Mice Alters Spontaneous Physical Activity and Protects Against Diet-induced Obesity |
|
| 4:30–5:00 PM |
Coffee Available |
British Columbia Foyer |
| 5:00–7:00 PM |
Obesity Co-Morbidities |
Columbia Ballroom |
| |
* Karine Clément, INSERM / Sorbonne Universite
Session Chair |
|
| |
Amalia Gastaldelli, Institute of Clinical Physiology
Cardiometabolic Risk, Insulin Resistance and Obesity |
|
| |
Philipp E. Scherer, University of Texas Southwestern Medical Center
Why does Obesity Cause Diabetes? |
|
| |
Sam Lockhart, Wellcome–MRC Institute of Metabolic Science, University of Cambridge
Short Talk: Short Talk: Damaging Mutations in LXRalpha Uncouple Lipogenesis from Hepatotoxicity and Implicate Hepatic Cholesterol Sensing in Human Liver Health |
|
| |
Reiner Jumpertz von Schwartzenberg, Helmholtz Center Munich
Short Talk: Short Talk: Mechanisms of Prediabetes Remission in People without Weight Loss and with Weight Gain |
|
| |
Meenakshi Gupta, National Institute of Health
Short Talk: Short Talk: G Proteins Gsa and Gq/11 in the Paraventricular Nucleus of the Hypothalamus (PVN) Mediate Distinct Cardiovascular and Metabolic Responses to Melanocortins |
|
| |
CK Wong, LTRI
Short Talk: Short Talk: Body Weight-independent Anti-inflammatory Effects of GLP-1R Agonists via the Neuronal GLP-1R |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 7:30–10:00 PM |
Poster Session 2 |
Pacific Ballroom, Vancouver Island Room |
Wednesday, February 7, 2024
| 7:00–8:00 AM |
Breakfast |
Pacific Ballroom, Vancouver Island Room |
| 8:00–11:00 AM |
Precision Obesity Management (Joint) |
Columbia Ballroom |
| |
* Abd A Tahrani, Novo Nordisk
Session Chair |
|
| |
Karine Clément, INSERM / Sorbonne Universite
Precision Obesity Medicine in Practice |
|
| |
Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute
The GLP1/GIP System in Obesity Management |
|
| |
Moneeza Siddiqui, Queen Mary University of London
Insights From Genetic and Observational Studies in South Asian Populations |
|
| |
Sarah Berry, King's College London
Personalized Nutrition in Obesity Management |
|
| |
Jordan B. Wean, University of Michigan
Short Talk: Short Talk: GABAergic GIPR-expressing Neurons are Required for the Body Weight Reduction caused by Dual Incretin Agonists |
|
| 9:00–9:20 AM |
Coffee Break |
British Columbia Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 3:00–4:30 PM |
Career Roundtable (Joint) |
British Ballroom |
| |
Jose C. Florez, Massachusetts General Hospital
Physician-in-Chief, Chair, and Professor |
|
| |
Leslie J. Baier, National Institutes of Health
Section Chief: Diabetes Molecular Genetics Section |
|
| |
Kyle Kai-How Farh, Illumina
VP & Distinguished Scientist |
|
| |
Sarah Berry, King's College London
Reader & Associate Professor |
|
| 4:30–5:00 PM |
Coffee Available |
British Columbia Foyer |
| 5:00–6:45 PM |
Obesity Co-Morbidities and New Therapeutic Avenues |
Columbia Ballroom |
| |
* Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School
Session Chair |
|
| |
Katherine R. Tuttle, University of Washington
Kidney Disease and Obesity |
|
| |
Murielle M. Véniant-Ellison, Amgen Inc.
Targeting GLP-1/GIPR in a Novel Bispecific Mechanism to Advance a Longer-acting Therapy for Weight Loss: Maridebart Cafraglutide (AMG 133) |
|
| |
Inderjeet Singh, Helmholtz Zentrum Munich
Short Talk: Short Talk: Nrac Regulates Fatty Acid Import in Adipocytes via Regulating CD36 Localization |
|
| |
Frederike Sass, University of Copenhagen
Short Talk: Short Talk: Dual Energy Expenditure and Appetite Control by Insulin-Sensitizing NK2R Agonism |
|
| |
Patrick Swan, Ulster University
Short Talk: Short Talk: Alpha-melanocyte Stimulatory Hormone (α-MSH): A Novel Mediator of Skeletal Muscle Glucose Uptake in Humans |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Columbia Ballroom |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Pacific Ballroom, Vancouver Island Room |
| 8:00–9:00 PM |
Cash Bar |
Pacific Ballroom, Vancouver Island Room |
Thursday, February 8, 2024
