Mitochondria Signaling and Disease (X5)
February 12-15, 2024
| Fairmont Banff Springs, Banff, AB, Canada
Heidi M. McBride and Timothy Wai
Scholarship Deadline: Nov. 8, 2023 | Abstract Deadline: Nov. 8, 2023 | Early Registration Deadline: Dec. 13, 2023
Monday, February 12, 2024
| 4:00–8:00 PM |
Arrival and Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
Tuesday, February 13, 2024
| 7:00–8:00 AM |
Breakfast |
Mezzanine 2 |
| 8:00–9:30 AM |
Welcome and Keynote Session (Joint) |
Van Horne B |
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* Heidi M. McBride, McGill University
Session Chair |
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* Jodi Nunnari, Altos Labs
Session Chair |
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Karin M. Reinisch, Yale University School of Medicine
Molecular basis for Inter-Organellar Lipid Transfer at Contact Sites |
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Edward T. Chouchani, Dana-Farber Cancer Institute
Building an Architecture of Functional Metabolite-Protein Interactions |
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| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 9:50–11:15 AM |
Mitochondrial Dynamics (Joint) |
Van Horne B |
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* Timothy Wai, Institut Pasteur
Session Chair |
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* Gia K. Voeltz, University of Colorado Boulder
Session Chair |
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Luca Scorrano, University of Padova
Unbiased Screenings Illuminate Regulators of Mitochondrial Dynamics and Contact Sites |
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Stefan Jakobs, Max Planck Institute for Multidisciplinary Sciences
Architecture of Mitochondria |
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Jodi Nunnari, Altos Labs
Lipid Trafficking at Mitochondria |
|
| 11:15–1:00 PM |
Poster Setup |
Mezzanine 2 |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–2:00 PM |
Career Roundtable (Joint) |
Van Horne C |
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Leon O. Murphy, Casma Therapeutics
Senior Vice President Biology |
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Ana J. García-Sáez, University of Cologne
Professor and Director of the Max Planck Institute of Biophysics |
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Tamas Balla, NICHD, National Institutes of Health
Senior Investigator |
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Dustin Hancks, University of Texas Southwestern Medical Center
Assistant Professor |
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| 1:00–10:00 PM |
Poster Viewing |
Mezzanine 2 |
| 2:30–4:30 PM |
Workshop 1: Hot Topics in Mitochondrial Biology (Joint) |
Van Horne B |
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* Tim Shutt, University of Calgary
Session Chair |
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Barbora Turpin Knotkova, Heidelberg University
Building Bridges: Reconstitution and Molecular Characterisation of the Mitochondrial Membrane Contact Site |
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Brandon Chen, University of Michigan
BRD4-Mediated Epigenetic Regulation of Endoplasmic Reticulum-Mitochondria Contact Sites is Governed by Mitochondria Complex III Function |
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Laurent Chatel-Chaix, Institut National de la Recherche Scientifique
Dengue Virus and Zika Virus Alter Endoplasmic Reticulum-Mitochondria Contacts to Regulate Respiration and Apoptosis |
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Lena Ho, Duke-NUS Medical School
Microproteins Mediate Localized Mitochondrial Translation to Drive OXPHOS |
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Marc Germain, Université du Québec à Trois-Rivières
Mitochondria- and ER-Associated Actin are Required for Mitochondrial Fusion |
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Juan Cruz Landoni, EPFL
Mitochondrial Pearling as a Putative Content Management Mechanism |
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Will Hofstadter, Princeton Universtiy
Infection-Induced Peripheral Mitochondria Fission Drives ER Encapsulations and Inter-Mitochondria Contacts that Rescue Bioenergetics |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Emerging Quality Control Mechanisms |
Van Horne B |
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* Shiori Sekine, University of Pittsburgh, Aging Institute
Session Chair |
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Hilla Weidberg, University of British Columbia
A Novel Role for Mitochondrial Targeting Sequences in Stress Signaling |
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Peter Rehling, University Medical Centre Göttingen
Regulating Mitochondrial Gene Expression |
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Xingguo Liu, Guangzhou Institutes of Biomedicine and Health
Mitolysosomes as New Pathway in Quality Control |
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Martin Graef, Cornell University
Short Talk: Short Talk: Autophagy Functions in Mitochondrial and Nuclear Genome Maintenance |
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Natalie Niemi, Washington University in St. Louis
Short Talk: Short Talk: PPTC7 Maintains Mitochondrial Protein Content by Suppressing Receptor-mediated Mitophagy |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Mezzanine 2 |
| 7:30–10:00 PM |
Poster Session 1 |
Mezzanine 2 |
Wednesday, February 14, 2024
| 7:00–8:00 AM |
Breakfast |
Mezzanine 2 |
| 8:00–11:00 AM |
Stress and Death Pathways |
Van Horne B |
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* Atan J. Gross, Weizmann Institute of Science
Session Chair |
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Ana J. García-Sáez, University of Cologne
Mitochondrial Membrane Remodeling During Death |
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Heidi M. McBride, McGill University
MDVs in Mitochondrial Homeostasis |
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Lucas T. Jae, Ludwig-Maximilians-University Munich
Genetic Dissection of Mitochondrial Stress in Human Cells |
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Timothy Wai, Institut Pasteur
Stress Responses and Cardiac Health |
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Hua Bai, Iowa State University
Short Talk: Short Talk: Role of Plasmalogen Ether Phospholipids in Mitochondrial Membrane Dynamics and Aging |
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Jordyn VanPortfliet, Texas A&M School of Medicine
Short Talk: Short Talk: Hyperinflammatory Antibacterial Innate Immunity and Elevated Lung Immunopathology in a Model of PolG-Related Mitochondrial Disease |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Mezzanine 2 |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Mezzanine 2 |
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Transfer of Mitochondria |
Van Horne B |
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* Marc Germain, Université du Québec à Trois-Rivières
Session Chair |
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Clair Crewe, Washington University School of Medicine in St. Louis
Inter-Organ Transport of Mitochondria |
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Minna Roh-Johnson, University of Utah
Mitochondrial Transfer in Cancer Models |
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Chiara Zurzolo, Institut Pasteur
Tunneling Nanotubes and Mitochondrial Transfer |
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Luana Naia, Karolinska Institutet
Short Talk: Short Talk: Bidirectional Neuron-astrocyte Mitochondrial Transfer in Alzheimer´s Disease |
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Akhila Rajan, Fred Hutchinson Cancer Center
Short Talk: Short Talk: Mitochondrial Components as Adipokines: A Novel Fat-brain Communication Modality |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
Mezzanine 2 |
| 7:30–10:00 PM |
Poster Session 2 |
Mezzanine 2 |
Thursday, February 15, 2024
| 7:00–8:00 AM |
Breakfast |
Mezzanine 2 |
| 8:00–11:00 AM |
Metabolic Rewiring in Cell Fate Decisions (Joint) |
Van Horne B |
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* Mary-Ellen Harper, University of Ottawa
Session Chair |
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Lydia Finley, Memorial Sloan Kettering Cancer Center
Identifying and Exploiting Cell State-Dependent Metabolic Networks |
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Jessica B. Spinelli, University of Massachusetts Chan Medical School
Unlocking the Potential of the Mammalian Electron Transport Chain |
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Carmela Sidrauski, CalicoLabs
ISR Tuning of Metabolism and Cell Fate in Homeostasis and Disease |
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Fabricio Loayza-Puch, German Cancer Research Center
Short Talk: Short Talk: Exploiting Mitochondrial Translation to Uncover Compartment-specific Metabolic Vulnerabilities |
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Daria Ilatovskaya, Medical College of Georgia
Short Talk: Short Talk: Sex Hormones-mediated Differences in Renal Mitochondrial Bioenergetics and Metabolism |
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Ryo Higuchi-Sanabria, University of Southern California
Short Talk: Short Talk: Branching Out From Actin Filaments: Actin and Organelle Homeostasis During Aging |
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Erica Kane, Western Univesity
Short Talk: Short Talk: Interrogating the Mechanistic Role of Integrated Stress Response in Microglial Polarity |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Mezzanine 2 |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Mezzanine 2 |
| 2:30–4:30 PM |
Workshop 2: Leading Edge Technologies: Mitochondrial Metabolism and Metabolomics (Joint) |
Van Horne B |
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* Sara Nowinski, Van Andel Institute
Session Chair |
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Isshin Shiiba, Gakushuin University
The Development of Organelle Contact Sites Quantification Tool and Exploration of the New Role of ER-Mitochondria Contact |
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Satoko Shinjo, Fondazione per la ricerca biomedica avanzata VIMM
Imaging Various Interorganellar Distances with STACCATO, a Reversible, Multispectral Split-FAST Mitochondria-ER Contacts Probe |
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Ahmad A. Cluntun, University of Utah, HHMI
MCT1 Facilitates Direct Mitochondrial Oxidation of Lactate in the Heart |
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Zak Baker, Washington University in St. Louis
Multiomic Profiling Reveals a Critical Role for Triacylgycerol Mobilization in Surmounting Mitochondrial Dysfunction |
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Ana Victoria Lechuga-Vieco, University of Oxford / The Kennedy Institute of Rheumatology
Metabolic Remodeling Through Mitochondrial Transfer: A Key to Enhanced Immune Responses |
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Gayathri Muthukumar, Whitehead Institute, MIT
Uncovering Biogenesis Pathways for Alpha-Helical Mitochondrial Outer Membrane Proteins Using Genome-Wide Approaches |
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–6:45 PM |
Mitochondria and Immunity |
Van Horne B |
| |
* Olaf Groß, University Medical Center Freiburg
Session Chair |
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Lena Pernas, University of California, Los Angeles and Max Planck Institute for Biology of Ageing
Organellar and Metabolic Dynamics of the Host-Pathogen Interaction |
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Robert O. Watson, Texas A&M University, School of Medicine
Mitochondrial ROS Promotes Susceptibility to Infection via Gasdermin D-Mediated Necroptosis |
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Julien Prudent, University of Cambridge
Inner Mitochondrial Membrane Remodeling and mtDNA Dynamics |
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Dustin Hancks, University of Texas Southwestern Medical Center
Short Talk: Short Talk: Rewiring of Mitochondrial Metabolism Invokes Subprograms of the Interferon Response to Adapt Host Defenses |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Van Horne B |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Mezzanine 2 |
| 7:30–10:00 PM |
Poster Session 3 |
Mezzanine 2 |
Friday, February 16, 2024
