Organelle Membrane Contact Sites in Health and Disease (X6)
February 12-15, 2024
| Fairmont Banff Springs, Banff, AB, Canada
Gia K. Voeltz and Jodi Nunnari
Scholarship Deadline: Nov. 29, 2023 | Abstract Deadline: Nov. 29, 2023 | Early Registration Deadline: Dec. 14, 2023
Monday, February 12, 2024
| 4:00–8:00 PM |
Arrival and Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
Tuesday, February 13, 2024
| 7:00–8:00 AM |
Breakfast |
Mezzanine 2 |
| 8:00–9:30 AM |
Welcome and Keynote Session (Joint) |
Van Horne B |
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* Heidi M. McBride, McGill University
Session Chair |
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* Jodi Nunnari, Altos Labs
Session Chair |
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Karin M. Reinisch, Yale University School of Medicine
Molecular basis for Inter-Organellar Lipid Transfer at Contact Sites |
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Edward T. Chouchani, Dana-Farber Cancer Institute
Insights into Dynamic Rewiring of Metabolism in Physiology |
|
| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 9:50–11:15 AM |
Mitochondrial Dynamics (Joint) |
Van Horne B |
| |
* Timothy Wai, Institut Pasteur
Session Chair |
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* Gia K. Voeltz, University of Colorado Boulder
Session Chair |
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Luca Scorrano, University of Padova
Unbiased Screenings Illuminate Regulators of Mitochondrial Dynamics and Contact Sites |
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Stefan Jakobs, Max Planck Institute for Multidisciplinary Sciences
Architecture of Mitochondria |
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Jodi Nunnari, Altos Labs
Lipid Trafficking at Mitochondria |
|
| 11:15–1:00 PM |
Poster Setup |
Mezzanine 2 |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–2:00 PM |
Career Roundtable (Joint) |
Van Horne C |
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Leon O. Murphy, Casma Therapeutics
Senior Vice President Biology |
|
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Ana J. García-Sáez, University of Cologne
Professor and Director of the Max Planck Institute of Biophysics |
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Tamas Balla, NICHD, National Institutes of Health
Senior Investigator |
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Dustin Hancks, University of Texas Southwestern Medical Center
Assistant Professor |
|
| 1:00–10:00 PM |
Poster Viewing |
Mezzanine 2 |
| 2:30–4:30 PM |
Workshop 1: Hot Topics in Mitochondrial Biology (Joint) |
Van Horne B |
| |
* Tim Shutt, University of Calgary
Session Chair |
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Barbora Turpin Knotkova, Heidelberg University
Building Bridges: Reconstitution and Molecular Characterisation of the Mitochondrial Membrane Contact Site |
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Brandon Chen, University of Michigan
BRD4-Mediated Epigenetic Regulation of Endoplasmic Reticulum-Mitochondria Contact Sites is Governed by Mitochondria Complex III Function |
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Laurent Chatel-Chaix, Institut National de la Recherche Scientifique
Dengue Virus and Zika Virus Alter Endoplasmic Reticulum-Mitochondria Contacts to Regulate Respiration and Apoptosis |
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Lena Ho, Duke-NUS Medical School
Microproteins Mediate Localized Mitochondrial Translation to Drive OXPHOS |
|
| |
Marc Germain, Université du Québec à Trois-Rivières
Mitochondria- and ER-Associated Actin are Required for Mitochondrial Fusion |
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Juan Cruz Landoni, EPFL
Mitochondrial Pearling as a Putative Content Management Mechanism |
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Will Hofstadter, Princeton Universtiy
Infection-Induced Peripheral Mitochondria Fission Drives ER Encapsulations and Inter-Mitochondria Contacts that Rescue Bioenergetics |
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Lipid Homeostasis |
Van Horne C |
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* Melody Subra, HHMI
Session Chair |
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Gia K. Voeltz, University of Colorado Boulder
Dynamics of Membrane Contact Sites |
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William A. Prinz, University of Texas Southwestern Medical Center
Lipid Trafficking at the PM |
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Robin Klemm, University of Oxford
Mitochondrial Remodeling During Adipocyte Differentiation |
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Kylie N Jacobs, University of Utah
Short Talk: Short Talk: Elucidating Connections Between Amino Acids, Contact Sites, and Lipids in Metabolic Toxicity: a Hidden Gem? |
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Xing Zeng, UT Southwestern medial center
Short Talk: Short Talk: CLSTN3B Enhances Adipocyte Lipid Droplet Structure and Function via Endoplasmic Reticulum Contact |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Mezzanine 2 |
| 7:30–10:00 PM |
Poster Session 1 |
Mezzanine 2 |
Wednesday, February 14, 2024
| 7:00–8:00 AM |
Breakfast |
Mezzanine 2 |
| 8:00–11:00 AM |
Getting to the Plasma Membrane |
Van Horne C |
| |
* Ryo Higuchi-Sanabria, University of Southern California
Session Chair |
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Laura L. Lackner, Northwestern University
Tethered to the Plasma Membrane |
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Jen Liou, University of Texas Southwestern Medical Center
Ca Trafficking at ER-PM Contact Sites |
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Tamas Balla, NICHD, National Institutes of Health
Moving Lipids |
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Kensuke Tsushima, University of California, Los Angeles
Short Talk: Short Talk: Spatiotemporal Phosphoinositide-AKT Signaling Regulates Myocardial T-tubule and Membrane Dynamics |
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Haavard Haukaas, Oslo University Hospital
Short Talk: Short Talk: The PI4K3a Complex: An Active Player at Membrane Contact Sites? |
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Hanlin Zhang, UC Berkeley
Short Talk: Short Talk: The Extracellular Matrix Integrates Mitochondrial Homeostasis to Promote Immunity |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Mezzanine 2 |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Mezzanine 2 |
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Molecular Trafficking |
Van Horne C |
| |
* Barbora Turpin Knotkova, Heidelberg University
Session Chair |
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Pedro Carvalho, University of Oxford
Lipid Droplet Formation |
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W. Mike Henne, UT Southwestern Medical Center
Lipid Droplet Crosstalk with the Cell Surface |
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György Hajnóczky, Thomas Jefferson University
Moving Calcium Back and Forth |
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Philipp Melchinger, University of Cologne
Short Talk: Short Talk: Identifying Novel Interorganellar Regulators of Adrenal Steroidogenesis |
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Bo Gong, Weill Cornell Medical College
Short Talk: Short Talk: ER-PM Contact Gradients Direct Cell Migration |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Mezzanine 2 |
| 7:30–10:00 PM |
Poster Session 2 |
Mezzanine 2 |
Thursday, February 15, 2024
| 7:00–8:00 AM |
Breakfast |
Mezzanine 2 |
| 8:00–11:00 AM |
Metabolic Rewiring in Cell Fate Decisions (Joint) |
Van Horne B |
| |
* Mary-Ellen Harper, University of Ottawa
Session Chair |
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Lydia Finley, Memorial Sloan Kettering Cancer Center
Tuning Cell Fate with Metabolism and Epigenetics |
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Jessica B. Spinelli, University of Massachusetts Chan Medical School
Unlocking the Potential of the Mammalian Electron Transport Chain |
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Carmela Sidrauski, CalicoLabs
ISR Tuning of Metabolism and Cell Fate in Homeostasis and Disease |
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Fabricio Loayza-Puch, German Cancer Research Center
Short Talk: Short Talk: Exploiting Mitochondrial Translation to Uncover Compartment-specific Metabolic Vulnerabilities |
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Daria Ilatovskaya, Medical College of Georgia
Short Talk: Short Talk: Sex Hormones-mediated Differences in Renal Mitochondrial Bioenergetics and Metabolism |
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Ryo Higuchi-Sanabria, University of Southern California
Short Talk: Short Talk: Branching Out From Actin Filaments: Actin and Organelle Homeostasis During Aging |
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Erica Kane, Western Univesity
Short Talk: Short Talk: Interrogating the Mechanistic Role of Integrated Stress Response in Microglial Polarity |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Mezzanine 2 |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Mezzanine 2 |
| 2:30–4:30 PM |
Workshop 2: Leading Edge Technologies: Mitochondrial Metabolism and Metabolomics (Joint) |
Van Horne B |
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* Sara Nowinski, Van Andel Institute
Session Chair |
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Isshin Shiiba, Gakushuin University
The Development of Organelle Contact Sites Quantification Tool and Exploration of the New Role of ER-Mitochondria Contact |
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Satoko Shinjo, Fondazione per la ricerca biomedica avanzata VIMM
Imaging Various Interorganellar Distances with STACCATO, a Reversible, Multispectral Split-FAST Mitochondria-ER Contacts Probe |
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Ahmad A. Cluntun, University of Utah, HHMI
MCT1 Facilitates Direct Mitochondrial Oxidation of Lactate in the Heart |
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Zak Baker, Washington University in St. Louis
Multiomic Profiling Reveals a Critical Role for Triacylgycerol Mobilization in Surmounting Mitochondrial Dysfunction |
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Ana Victoria Lechuga-Vieco, University of Oxford / The Kennedy Institute of Rheumatology
Metabolic Remodeling Through Mitochondrial Transfer: A Key to Enhanced Immune Responses |
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Gayathri Muthukumar, Whitehead Institute, MIT
Uncovering Biogenesis Pathways for Alpha-Helical Mitochondrial Outer Membrane Proteins Using Genome-Wide Approaches |
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–6:00 PM |
Membrane Dynamics |
Van Horne C |
| |
* Kylie N Jacobs, University of Utah
Session Chair |
|
| |
Elizabeth Chen, UT Southwestern Medical Center
The Fusogenic Synapse |
|
| |
Adam Frost, Altos Labs
Mechanisms of Membrane Dynamics |
|
| |
Maya B. Schuldiner, Weizmann Institute of Science
New Pathways for Membrane Contact |
|
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Christina Towers, The Salk Institute for Biological Studies
Metabolic Adaptations to Autophagy Inhibition in Cancer |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Van Horne C |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
Mezzanine 2 |
| 7:30–10:00 PM |
Poster Session 3 |
Mezzanine 2 |
Friday, February 16, 2024
