| 4:00–8:00 PM | Registration | Riverview Lounge |
| 6:00–8:00 PM | Welcome Mixer | Riverview Lounge |
| 7:00–8:00 AM | Breakfast | Alberta/New Brunswick |
| 8:00–9:00 AM | Welcome and Keynote Address (Joint) | Cascade Ballroom |
| * Karen Adelman, Harvard Medical School Session Chair |
| Patrick Cramer, Max Planck Institute for Multidisciplinary Sciences Chromatin and Transcription |
| 9:00–11:30 AM | Mechanisms of Gene Control and Epigenetic Regulation (Joint) | Cascade Ballroom |
| * Seychelle Vos, Massachusetts Institute of Technology Session Chair |
| Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research Controlling CpG islands |
| François Fuks, University of Brussels RNA Modifications in Health and Disease |
| Lacramioara Bintu, Stanford University High-Throughput Measurements of Activation and Repression Domains from Human Proteins |
| Havva Ortabozkoyun, University of Miami / HHMI Short Talk: Members of an Array of Zinc Finger Proteins Specify Distinct Hox Chromatin Boundaries |
| 9:30–9:50 AM | Coffee Break | Riverview Lounge |
| 9:50–9:55 AM | Award Recipient Acknowledgement | Cascade Ballroom |
| 11:30–1:00 PM | Poster Setup | Alberta/New Brunswick |
| 11:30–2:30 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Alberta/New Brunswick |
| 2:30–4:30 PM | Symposia Spotlight 1: Epigenetics and Cancer | Cascade Ballroom |
| * Kristian Helin, The Institute of Cancer Research Session Chair |
| Pablo R Freire, Dana-Farber Cancer Institute Large AT-rich Promoter Flanks Control Menin/KMT2A Complex Localization at Key Developmental Genes |
| Jun Ho Lee, Memorial Sloan Kettering Cancer Center Joint TGF-β and RAS Transcriptional Program Supports Metastasis |
| Tom A Milne, University of Oxford Aberrant Enhancer Activation in KMT2A: AFF1 Leukemia |
| Mara Steiger, Hasso Plattner Institute for Digital Engineering Rapid Brain Tumor Classification from Sparse Epigenomic Data |
| Wazim Mohammed Ismail, Mayo Clinic Single Cell Multiomics Reveal Divergent Effects of DNMT3A and TET2 Mutant Clonal Hematopoiesis in Inflammatory Response |
| Hsiao P. J. Voon, Monash University The Paediatric Glioma H3.3 K27M Mutation Disrupts Cell Differentiation by Interfering with Heterochromatin Formation at Pericentric Regions |
| David Spencer, Washington University in St. Louis Blocks of Sequence-Independent Allele-Specific DNA Methylation in Acute Myeloid Leukemia are Clonal Events that can Originate in Normal Hematopoietic Cells |
| Aaron D. Viny, Columbia University Irving Medical Center FLI1 Accessible Stem Cell Programs Drive Leukemic Transformation |
| 4:30–5:00 PM | Coffee Break with Hot Chocolate, Firepits & Mountain Views | Conservatory Terrace |
| 5:00–7:00 PM | Histone Modifications: Cause or Cog in Gene Regulation? | Cascade Ballroom |
| * Yang Shi, Ludwig Institute for Cancer Research, Oxford Branch Session Chair |
| Kristian Helin, The Institute of Cancer Research Dissecting the Role of Histone Modifications Using Histone Mutants |
| Nicola Iovino, Max Planck Institute of Immunobiology and Epigenetics Catalytic-Independent Functions of CPB/P300 |
| Shelley L Berger, University of Pennsylvania Functional Consequences of Histone Acetylation |
| Mark Pownall, UCSF Short Talk: Heterochromatin Form and Function during Vertebrate Development |
| Michael S Werner, University of Utah Short Talk: Histone 4 Acetylation Regulates Developmental Plasticity of Predatory Nematodes |
| 7:00–8:00 PM | Social Hour with Lite Bites | Alberta/New Brunswick |
| 7:30–10:00 PM | Poster Session 1 | Alberta/New Brunswick |
| 7:00–8:00 AM | Breakfast | Alberta/New Brunswick |
| 8:00–11:00 AM | Epigenetics in Cellular Plasticity and Development | Cascade Ballroom |
| * Giacomo Cavalli, Institute of Human Genetics Session Chair |
| Luciano Di Croce, CRG - Center for Genomic Regulation Polycomb Complexes in Development |
| Karen Adelman, Harvard Medical School Dynamic Changes in Chromatin and Transcription During Cell Differentiation |
| Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics The Influence of Histone Modifications and Chromatin Domains on Biallelic Gene Expression |
| Mark A. Dawson, Peter MacCallum Cancer Centre Functional Genomics to Study Transcription Factors and Chromatin Remodelers in Cancer |
| Evgeny Kvon, University of California, Irvine Short Talk: Bystander Chromatin Poising by Pioneer Factors Confers Aberrant Enhancer Activation in Congenital Disease |
| Selin Jessa, Stanford University Short Talk: Dissecting the Cooperative, Context-dependent Rules of Transcription Factor Binding in Human Development |
| 9:00–9:20 AM | Coffee Break | Riverview Lounge |
| 11:00–1:00 PM | Poster Setup | Alberta/New Brunswick |
| 11:00–3:00 PM | On Own for Lunch |
| 1:00–2:30 PM | Career Roundtable (Joint) | Alhambra |
| Paola Scaffidi, European Institute of Oncology Group Leader |
| Gromek Smolen, Foghorn Therapeutics VP, Head of Biology |
| Evan J. Worden, Van Andel Institute Assistant Professor |
| Michael S Werner, University of Utah Assistant Professor |
| Ivanka D Kamenova, Nature Protocols Senior Editor |
| 1:00–10:00 PM | Poster Viewing | Alberta/New Brunswick |
| 3:00–4:15 PM | Innate and Environmental Impacts on Epigenetic Regulation | Cascade Ballroom |
| * Mark A. Dawson, Peter MacCallum Cancer Centre Session Chair |
| Jo Iversen, University of Copenhagen Short Talk: Exposure to Childhood Maltreatment is Associated with Specific Epigenetic Patterns in Sperm |
| Kian Koh, Baylor College of Medicine Short Talk: Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Malformations through Dysregulation of DNA Methylation |
| Lei Hou, Boston University School of Medicine Short Talk: Genetic, Epigenomic, and Phenotypic Integration Reveals the Roles of Circulating Immune Cells and Patient Subgroups in Bipolar Disorder |
| Audrey Houle, McGill University Short Talk: CTCF is Required for Breast Tumour Initiation, but is Dispensable for Normal Mammary Gland Development |
| 4:30–5:00 PM | Coffee Available | Riverview Lounge |
| 5:00–7:00 PM | Epigenetics and Metabolism | Cascade Ballroom |
| * Shelley L Berger, University of Pennsylvania Session Chair |
| Kathryn E. Wellen, University of Pennsylvania Metabolic Control of Chromatin Modifications |
| Navdeep S Chandel, Northwestern University Mitochondrial Signaling to the Transcription Machinery |
| Lydia Finley, Memorial Sloan Kettering Cancer Center Metabolic Pathways Govern Cell Fate Decisions |
| Gabriel Alzial, IRIC, Université de Montréal Short Talk: Mitochondrial Stress Modulates Chromatin Accessibility and Cell Identity in Breast Cancer |
| Subhamoy Dasgupta, Roswell Park Comprehensive Cancer Center Short Talk: Nuclear Specific Reductive Carboxylation of Alpha-ketoglutarate Fuels Histone Acetylation |
| 7:00–8:00 PM | Social Hour with Lite Bites | Alberta/New Brunswick |
| 7:30–10:00 PM | Poster Session 2 | Alberta/New Brunswick |
| 7:00–8:00 AM | Breakfast | Alberta/New Brunswick |
| 8:00–11:00 AM | DNA Methylation and Epigenetic Inheritance | Cascade Ballroom |
| * François Fuks, University of Brussels Session Chair |
| Robert A. Martienssen, Cold Spring Harbor Laboratory Epigenetic Memory in Plants |
| Giacomo Cavalli, Institute of Human Genetics Three Dimensional Genome Organization and Epigenetic Memory |
| Evan J. Worden, Van Andel Institute The Structural Basis for de novo DNA Methylation in Chromatin |
| Samuel C Agius, Monash University Short Talk: Allosteric Effectors of PRC2 Synergise to Restrict the Spread of Polycomb Domains |
| Jasbeer S Khanduja, Massachusetts General Hospital Short Talk: LncRNA-Mediated Heterochromatin Assembly |
| Ellen Weinzapfel, EpiCypher, Inc. Short Talk: Advanced Multiomic Sequencing Technologies Reveal Complex Crosstalk between Chromatin Proteins and DNA Methylation in Development |
| 9:00–9:20 AM | Coffee Break | Riverview Lounge |
| 11:00–2:30 PM | On Own for Lunch |
| 2:30–4:30 PM | Symposia Spotlight 2: Epigenetics in Development | Cascade Ballroom |
| * Karen Adelman, Harvard Medical School Session Chair |
| Jan Zylicz, University of Copenhagen HDAC3 Functions as a Speed-limit for Developmental Enhancers |
| Richard Pan, Columbia University Transgenic Mouse Models for Editing DNA Methylation in vivo |
| Andrew S Koh, University of Chicago Chromatin Accessibility Noise is Amplified via p53 Repression to Promote Cell Plasticity for Immune Tolerance |
| Alyssa Erickson, Washington University School of Medicine The Role of Histone Ubiquitination in Plasticity and Neurodevelopmental Disease |
| Kiera Malone, University of Vermont Chromatin Recognition by the AAA+ ATPase Superfamily Protein ATAD2B |
| H. Courtney Hodges, Baylor College of Medicine A Molecular Adapter that Mediates Disordered cBAF Interactions |
| Eva Neugebauer, University Medical Center Freiburg Herpesviruses Mimic Zygotic Genome Activation to Promote Viral Replication |
| Nathan Palpant, University of Queensland Rare Regions of Facultative Heterochromatin Define Domains of Cellular Constraint Underpinning Genomic Regulation of Cell Identity |
| 4:30–5:00 PM | Coffee Available | Riverview Lounge |
| 5:00–5:45 PM | Keynote Address (Joint) | Cascade Ballroom |
| * Seychelle Vos, Massachusetts Institute of Technology Session Chair |
| Yang Shi, Ludwig Institute for Cancer Research, Oxford Branch Chromatin Regulation and Cancer |
| 5:45–7:15 PM | Transcription and Epigenetics in Disease (Joint) | Cascade Ballroom |
| * Kristian Helin, The Institute of Cancer Research Session Chair |
| Paola Scaffidi, European Institute of Oncology Epigenetics and Functional Intratumor Heterogeneity |
| Gromek Smolen, Foghorn Therapeutics Targeting Chromatin Modulators with Therapeutic Degraders |
| Tony Kouzarides, Gurdon Institute, University of Cambridge Targeting RNA Modifying Enzymes in the Treatment of Cancer |
| 7:15–7:30 PM | Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint) | Cascade Ballroom |
| 7:30–8:30 PM | Social Hour with Lite Bites | Alberta/New Brunswick |
| 12:00–11:59 PM | Departure |