Innate Immunity Across the Molecular, Cellular, Tissue and Therapeutic (Z1)
April 9-12, 2024
| Fairmont Banff Springs, Banff, AB, Canada
Kate L. Jeffrey, Ramnik Xavier and Xu Zhou
Scholarship Deadline: Jan. 18, 2024 | Abstract Deadline: Jan. 18, 2024 | Early Registration Deadline: Feb. 8, 2024
| 4:00–8:00 PM |
Arrival and Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
Wednesday, April 10, 2024
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–9:00 AM |
Welcome and Keynote Address |
Van Horne A |
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Ramnik Xavier, Massachusetts General Hospital
Variants Linked to Functional Phenotypes and Causal Mechanisms in Relevant Cell Types |
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| 9:00–11:15 AM |
Sensing of Microbial Friends and Enemies |
Van Horne A |
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Marco Colonna, Washington University School of Medicine
Activating and Inhibitory Innate Immune Receptors in Neurodegeneration |
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Virginia Pascual, Cornell University
Talk Title to be Announced |
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Nandan S Gokhale, University of Washington
Short Talk: Short Talk: Cellular RNA Interacts with MAVS to Promote Antiviral Signaling |
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Diep H. Nguyen, MIT/Whitehead Institute
Short Talk: Short Talk: Spatial Gradients of Pathogen-sensing Capability Confer a Tiered Tissue Self-Defense System |
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| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 11:15–1:00 PM |
Poster Setup |
Van Horne C |
| 11:15–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 2:30–4:30 PM |
Workshop 1: Inflammasomes in Sickness and in Health |
Van Horne A |
| |
Daniel Okin, Massachusetts General Hospital
Tissue Stiffness is a Fundamental Regulator of NLRP3 Inflammasome Activities |
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Pritisha Rozario, Nanyang Technological University
Mechanistic Basis for Potassium Efflux Driven Activation of the Human NLRP1 Inflammasome |
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Ben A. Croker, University of California San Diego
GSDME Promotes PAD4 Activation and DNA Externalization from Apoptotic Neutrophils |
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Maria Luisa Gil Marques, Massachusetts General Hospital. Harvard Medical School
Interaction Between NLRP11, CASP4, and LPS in the Context of the Innate Immune Response to Bacterial Pathogens |
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Charles L. Evavold, Harvard University
Sterol-izing Immunity: Cholesterol Control of Mammalian Gasdermins |
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Simone Caielli, Weill Cornell Medical College - Drukier Institute For Children's Health
An Unconventional Mechanism of IL-1b Secretion that Requires Type I IFN in SLE Monocytes |
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Tsan Sam Xiao, Case Western Reserve University
S-palmitoylation of Gasdermins Regulate Their Function in Membrane Pore Formation and Pyroptotic Cell Death |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Innate Immunity 2.0: Epigenetics |
Van Horne A |
| |
Kate L. Jeffrey, Moderna and Harvard Medical School
Chromatin Readers and Inflammation |
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Steven Z. Josefowicz, Weill Cornell Medical College
Signaling to Chromatin for Rapid Innate Immunity |
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Liraz Galia, UTSW Medical center
Talk Title to be Announced |
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Theresa Alenghat, Cincinnati Children’s Hospital
Epigenetic Regulation of the Host-microbiota Relationship |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
President's Hall |
| 7:30–10:00 PM |
Poster Session 1 |
Van Horne C |
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Innate Immunity in 3D |
Van Horne A |
| |
Xu Zhou, Boston Children's Hospital
Environmental Control of Inflammatory Response |
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Miguel Soares, Instituto Gulbenkian de Ciência
Tissue Tolerance to Infection |
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Andrés Hidalgo, Yale School of Medicine
Neutrophil Dynamic Behavior |
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Sacha Lebon, Weizmann Institute of Science
Short Talk: Short Talk: Dissecting a Novel Stem-Cell Defense Mechanism in Early Epithelial-Specific Responses to an Enteric Bacterial Pathogen |
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Alexandra Wells, University of Texas Southwestern Medical Center
Short Talk: Short Talk: Characterization of Interferon-Induced Gene Expression in the Mouse Lung and Liver |
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Elizabeth F Rowland, University of Illinois at Urbana-Champaign
Short Talk: Short Talk: High Resolution 3D Spatial-Temporal Mapping of Influenza A Virus Infection and Innate Immune Signaling in Whole Lung Organs Reveals the Early Spatial Interplay of Viral Spread and Host Response |
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Julia Bayer, University of Bern
Short Talk: Short Talk: Spatial Transcriptomics Reveals Interaction of Mesothelial Cells with Injury-Derived Osteopontin in Serosal Scarring |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Van Horne C |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Van Horne B |
| |
Sarah Teichmann, Wellcome Sanger Institute
Head of Cellular Genetics and Senior Group Leader, Co-Founder and Principal Leader of Human Cell Atlas |
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Kara Lassen, Roche
VP and Global Head, Immunology Therapeutic Area |
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Bryan D. Bryson, Massachusetts Institute of Technology
Associate Professor |
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Jonathan Sockolosky, Curie.Bio
Senior Director, CSO Partner Team |
|
| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Innate Immune Protectors and Drivers of Disease |
Van Horne A |
| |
Yasmine Belkaid, Pasteur Institut
Remote Presentation: Microbial Control of Tissue Threshold of Activation |
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Bryan D. Bryson, Massachusetts Institute of Technology
Unraveling TB Granuloma Phagocyte Heterogeneity |
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Kara Lassen, Roche
Fibroblasts in Chronic Inflammatory Diseases |
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Hernandez Moura Moura Silva, Massachusetts Institute of Technology
Short Talk: Short Talk: Decoding Immune Mediated Circuits Supporting Tissue Physiology |
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Disha Sood, Sanofi
Short Talk: Short Talk: Astrocyte Sensitivity to Nucleic Acid Agonism Contributes to Neurodegeneration in iPSC-Derived Tri-Culture Models of Amyotrophic Lateral Sclerosis |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
President's Hall |
| 7:30–10:00 PM |
Poster Session 2 |
Van Horne C |
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
The Emerging, Unexpected and New Frontiers (Joint) |
Van Horne A |
| |
Sarah Teichmann, Wellcome Sanger Institute
Cell Atlas Mapping of the Immune System Across Organs |
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Graham Heimberg, Genentech, Inc.
SCimilarity Queries Reveal Connections across Macrophage Populations |
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Nicolas Chevrier, University of Chicago
Decoding the Body Language of Immunity |
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Subhajit Poddar, University of Pennsylvania
Short Talk: Short Talk: STING Modulates Golgi pH, Cargo Sorting, and Secretion Through ArfGAP2 |
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Toufic Mayassi, Broad Institute
Short Talk: Short Talk: Molecular Cartography Reveals Robust, Adaptable, and Resilient Intestinal Networks |
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Shubham Tripathi, Yale School of Medicine
Short Talk: Short Talk: Role of a Cellular Circuit Involving IFN-γ / IL-15 Positive Feedback in Establishing Antigen-Non-Specific Immune Memory |
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Tomer Milo, Weizmann Institute of Science
Short Talk: Short Talk: A Paradox of Foreign-Specific Regulatory T Cells and a Proposed Resolution by a Lymph Node Microdomain Theory |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Workshop 2: Single Cell to Tissue-Level Immunity |
Van Horne A |
| |
Ayshwarya Subramanian, Cornell University
Immune Checkpoint Molecule Tim-3 Regulates Microglial Function and the Development of Alzheimer’s Disease Pathology |
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Tasuku Nishimura, Kumamoto University
Non-Canonical Type I Interferons are Induced by Cholesterol Restriction and Prime RIG-I-Mediated Antiviral Innate Immune Responses |
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Rio Sugimura, HKU
Cancer and Vascular Immune Assembloids Model the Oncofoetal Niche in the Solid Tumor Microenvironment |
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Stephanie Hajjar, Boston Children's Hospital
Exploring the Role of GPR65-Mediated pH Sensing in Tuning Systemic and Local Immune Responses |
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Kiara Wiggins, UC Irvine
TLR4’S Impact on Pcos Outcomes in Letrozole-induced Mouse Model |
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Siyan Cao, Washington University in St. Louis
Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets |
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Victoria Schuster, Oregon Health and Sciences University
Multi-Antigen Management by Dendritic Cells Within the Melanoma Microenvironment |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–6:45 PM |
Therapeutics - Leveraging and Avoiding Innate Immunity |
Van Horne A |
| |
Joseph R. Arron, Sonoma Biotherapeutics
Engineered Treg Therapies for Inflammatory Disorders |
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Martin Oft, Synthekine
Talk Title to be Announced |
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Eicke Latz, University of Bonn
Drugging Innate Immunity |
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Lingyin Li, Stanford University and Arc Institute
Short Talk: Short Talk: Chemical Biology of Extracellular cGAMP Signaling in Health and Disease |
|
| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Van Horne A |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
President's Hall |
| 8:00–9:00 PM |
Trivia! |
Van Horne A |
| 8:00–9:00 PM |
Cash Bar |
President's Hall |
