| 4:00–8:00 PM | Registration | Macdonald Foyer |
| 6:00–8:00 PM | Welcome Mixer | Macdonald Foyer |
| 7:00–8:00 AM | Breakfast | Woodlands Terrace |
| 7:30–8:00 AM | Poster Setup | Macdonald EF |
| 7:30–5:00 PM | Poster Viewing | Macdonald EF |
| 8:00–9:45 AM | Welcome and Keynote Session (Joint) | Macdonald ABCD |
| * Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School Session Chair |
| * Quinton Smith, University of California, Irvine Session Chair |
| Matthew F Krummel, University of California, San Francisco Tissue Archetypes Across Space and Time |
| Gordana Vunjak-Novakovic, Columbia University Organs-on-Chip Models for Studying Human Pathophysiology |
| 9:45–10:15 AM | Coffee Break | Macdonald Foyer |
| 10:15–10:20 AM | Award Recipient Acknowledgement | Macdonald ABCD |
| 10:20–11:30 AM | High-Throughput Approaches to Model Cells and Tissues (Joint) | Macdonald ABCD |
| * Chrysothemis Brown, Sloan Kettering Institute Session Chair |
| * Quinton Smith, University of California, Irvine Session Chair |
| Dana Pe'er, Memorial Sloan Kettering Cancer Center Plasticity in the Tissue Context |
| Peter Winter, Broad Institute Defining, Modeling, and Targeting Cell States in Cancer |
| 11:30–12:30 PM | Lunch | Woodlands Terrace |
| 12:00–2:30 PM | Poster Session 1 | Macdonald EF |
| 2:30–4:30 PM | Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions | Macdonald AB |
| Han Chen, Gladstone Institutes Multi-Task Learning for Context-Specific Representations of Cell States |
| * Samantha Riesenfeld, University of Chicago Modeling Cell-State Transitions in the Tissue Niche |
| Jian Ma, Carnegie Mellon University Multiscale Delineation of Cellular Interactions in Tissues |
| Yakir Reshef, Brigham and Women's Hospital Powerful and Accurate Case-Control Analysis of Spatially Resolved Molecular Data |
| Jagadish Sankaran, Genome Institute of Singapore Multimodal Inference of Morphogenomic Phenotypes Using Morphology and Expression Data Optimal Clustering (MEDOC) |
| Weiruo Zhang, Stanford University MONTAGE: A Computational Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities |
| Jana T Winterstein, German Cancer Research Center (DKFZ) Unveiling Phenotypic Plasticity in Melanoma: a Novel Computational Approach to Quantify Transcriptional Heterogeneity |
| Christian Reardon-Lochbaum, Boston Children's Hospital Single Cell Spatial Transcriptomics in Mouse Bone Marrow Reveals Age Dependent Cellular Structures |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–7:00 PM | Biologically-Motivated Analytical Methods to Deconstruct Tissues | Macdonald AB |
| Holger Heyn, CNAG-CRG The Power of a Million Cells |
| * Ricardo Ramirez, European Bioinformatics Institute Knowledge-Based Computational Approaches to Dissect Multi-Cellular Programs from Single-Cell and Spatial Data |
| Peter V. Kharchenko Downstream Impact of Segmentation Errors in Spatial Analysis |
| Aki Minoda, Radboud University Mukin Mouse Ageing Atlas: How Microbiota affects Ageing |
| 7:00–8:00 PM | On Own for Dinner |
| 7:00–8:00 AM | Breakfast | Woodlands Terrace |
| 8:00–11:00 AM | Learning from Human and Animal Variation | Macdonald AB |
| Monique van der Wijst, University Medical Center Groningen, UMCG Lessons Learned from the Single-Cell eQTL Consortium |
| Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School Charting Inflammatory Disease Trajectories in Human Barrier Tissues |
| Karin Pelka, Gladstone Institutes and University of California, San Francisco Spatially Organized Multicellular Immune Hubs |
| Paul G. Thomas, St. Jude Children's Research Hospital Genetic and Infectious Drivers of Human Immune Variation |
| * Sara Viragova, UCSF Short Talk: Examining The Role Of Memory In Intestinal Regeneration |
| Manu Setty, Fred Hutchinson Cancer Center Short Talk: Desynchronization Between Gene Expression And Chromatin Reveals Mechanisms Driving Cell State Change |
| 9:00–9:20 AM | Coffee Break | Macdonald Foyer |
| 11:00–1:00 PM | Poster Setup | Macdonald EF |
| 11:00–3:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Macdonald EF |
| 1:30–2:45 PM | Career Roundtable (Joint) | MacDonald CD |
| Oscar J. Abilez, Stanford University Senior Scientist-Stanford & Co-Founder-Bullseye Biotechnologies |
| Giuliana Rossi, Roche Institute of Human Biology Senior Scientist |
| Lei Tang, Nature Methods Senior Editor |
| 3:00–4:30 PM | Advances in Single Cell Biology and Organoids for Precision Medicine (Joint) | Macdonald AB |
| * Quinton Smith, University of California, Irvine Session Chair |
| * Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School Session Chair |
| Oshiomah Oyageshio, University of California Davis Remote Presentation: Integrating Single Cell Multiomics and Ancestry to Investigate TB susceptibility |
| Joshua De Sousa Casal, Boston Children's Hospital Early Life Development of The Pediatric Duodenum Across Distinct Geographical Environments |
| Kaitriana Colling, University of Iowa Lead Compound Identification Using Live-Cell Imaging of Patient-Derived Endometrial Cancer Organoids |
| Hyung-Sik Kim, Pusan National University TGFβ2-Driven Iron Dysregulation and Ferroptosis in Salivary Glands Trigger Hyposalivation Under Postmenopausal Conditions |
| Gat Rauner, Tufts University School of Medicine Next-Generation Breast Organoids as a Platform for Studying Human Lactation and Breast Tissue Regeneration |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–6:30 PM | New Biology of Cell Types, Subsets, States and Clones | Macdonald AB |
| Andrew RJ Lawson, Wellcome Sanger Institute Somatic Mutations in Health and Disease |
| Chrysothemis Brown, Sloan Kettering Institute Novel Antigen Presenting Cells in Early Life Immune Tolerance |
| Karan R Kathuria, Stanford University Short Talk: Synapse-Seq of Human Immune Cell Interactions Reveals Cytotoxic T Cell Suppression of Autoantibody Production |
| * Veronika Niederlova, Institute of Molecular Genetics Short Talk: Manipulating Effector and Memory Fates in CD8+ T cells: a Novel Tpam Transitional State and the Role of TGF-B |
| 7:00–8:00 PM | Social Hour with Lite Bites | Woodlands Terrace |
| 7:30–10:00 PM | Poster Session 2 | Macdonald EF |
| 7:00–8:00 AM | Breakfast | Woodlands Terrace |
| 8:00–11:15 AM | From Community-Engaged Research to Drug Discovery | Macdonald AB |
| Andreas Moor, ETH Remote Presentation: Systematic Perturbation of Cellular Interactions in the Tumor Microenvironment |
| * Sara Suliman, University of California, San Francisco Community-Based Single-Cell Research |
| Tommaso Biancalani, Genentech Foundation Models for Target Identifications |
| Daniel B. Burkhardt, NVIDIA Accelerating the Development of Virtual Cells |
| Miranda Orr, Washington University in St Louis, MO Short Talk: Highest-Plex Single-Cell Spatial Whole Transcriptome and 1000+ Proteome Identify a New Cell Type and Neural State in Alzheimer’s Disease Brains |
| Hamish W King, Walter and Eliza Hall Institute Short Talk: Pooled Single-cell CRISPR Screening In Primary Human B Cells Discovers Gene Targets And Pathways Of Non-Coding Autoimmune Risk Loci |
| Joan Camunas-Soler, University Of Gothenburg Short Talk: High-Resolution Spatial Transcriptomics And Functional Imaging Reveal Cellular Heterogeneity In The Human Pancreas |
| 9:00–9:20 AM | Coffee Break | Macdonald Foyer |
| 9:20–9:25 AM | People's Choice Poster Award Announcement | Macdonald AB |
| 11:15–2:30 PM | On Own for Lunch |
| 2:30–4:30 PM | Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions | Macdonald AB |
| * Nicholas F Kuhn, University of California, San Francisco Identification of a Novel Fibroblast State and Associated Cellular Changes via Local In Vivo Gene Editing in Cancer |
| Hope Anderson, University of Chicago Germline- And Non-Germline-Encoded Variation In The TCR Repertoire Impacts Gut-Resident γδ T Cell Activation And Function |
| Stefan Schattgen, St Jude Children's Research Hospital A Multimodal Single-Cell Atlas Charts Phenotypic Landscapes Of T Cell Receptor Convergence |
| Idan Milo, Weizmann Institute of Science Immune Organization In Sentinel Lymph Nodes Of Melanoma Patients Is Prognostic Of Distant Metastases |
| Robert Piscopio, University of California, Santa Barbara Photolabile Oligonucleotides Combined with Topologically Imposed Light Gradients Enable Spatially Resolved Single-Cell Transcriptomics and Epigenomics |
| Massimiliano Pagani, IFOM ETS - The AIRC Institute of Molecular Oncology Single-Cell Enhancerome Profiling Identifies Key Transcriptional Regulators of Human Tumor-Infiltrating Treg Cells |
| Prakrithi Pavithra, University of Queensland SPanC-Lnc : Decoding the Spatial and Single Cell Landscape of Long Non-coding RNAs at a Pan-Cancer Level |
| Nate Hyams, Clemson University Pericytes Promote Multiple Mechanisms of Cardiac Organoid Optimization for Cardiac Regeneration |
| 4:30–5:00 PM | Coffee Available | Macdonald Foyer |
| 5:00–6:45 PM | Ex Vivo and In Vivo Reconstruction of Tissues | Macdonald AB |
| * Samuel Kazer, Boston Children's Hospital & Harvard Medical School Session Chair |
| Alex K. Shalek, Massachusetts Institute of Technology From Correlation to Causation: Improving Human Disease Representation in vitro for Functional Testing of in vivo-Derived Hypotheses |
| Chris Tape, University College London Single-Cell Phenoscaping of Tumour Microenvironment Organoids |
| Jeffrey Moffitt, Boston Children's Hospital The Role of Spatial Organization in the Gut-Microbiome Interface in Gut Inflammation |
| Lingting Shi, Columbia University Short Talk: Multi-Omics Immune Profiling of Graft-Versus-Host Disease (GvHD) In Humans |
| 6:45–7:00 PM | Meeting Wrap-Up: Outcomes and Future Directions and Survey (Organizers) | Macdonald AB |
| 7:00–8:00 PM | Social Hour with Lite Bites | Woodlands Terrace |
| 12:00–11:59 PM | Departure |