Systems and Engineering Immunology: Advancing Immunological Insights in Health and Disease (Z2)
April 9-12, 2024
| Fairmont Banff Springs, Banff, AB, Canada
John Tsang, Shannon J Turley and Alex Marson
Scholarship Deadline: Jan. 18, 2024 | Abstract Deadline: Jan. 18, 2024 | Early Registration Deadline: Feb. 8, 2024
| 4:00–8:00 PM |
Arrival and Registration |
Van Horne Foyer |
| 6:00–8:00 PM |
Welcome Mixer |
Van Horne Foyer |
Wednesday, April 10, 2024
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Systems Immunology: Signatures and Mechanisms |
Van Horne B |
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Mark M. Davis, Stanford University School of Medicine, Howard Hughes
Of Human, Mouse, and Organoid Immune Systems |
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John Tsang, Yale University School of Medicine
The Systems Immunology of Immune Set Points |
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Aleksandra Walczak, École Normale Supérieure
Decoding Immune Repertoires |
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Rachelly Normand, Massachusetts General Hospital
Short Talk: Short Talk: Modeling the Effect of Immune Cell Infiltration on Tissue Function Reveals Cellular Rewiring Driving Human Thyroid Autoimmunity |
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Guangbo Chen, Stanford University
Short Talk: Short Talk: Pre-Vaccination Type I Interferon Abundance is Rate-Limiting for Post-Vaccination Influenza Antibody Response Among Human Populations |
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| 9:30–9:50 AM |
Coffee Break |
Van Horne Foyer |
| 11:15–1:00 PM |
Poster Setup |
Van Horne C |
| 11:15–5:00 PM |
On Own for Lunch |
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| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 2:30–4:30 PM |
Workshop 1: Organoids and Model Systems for Systems and Engineering Immunology |
Van Horne B |
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Yuri Pritykin, Princeton University
Ultra-Long-Range and Interchromosomal Looping and Compartmentalization in Regulatory T Cell Genome |
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Stefan Schattgen, St Jude Children's Research Hospital
MetaCoNGA: A Comprehensive Multi-Modal Index of Human T Cell Phenotype and Specificity |
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Alma-Martina Cepika, Stanford School of Medicine
Integration of Systems Biology Analysis and CRISPR-based Functional Epigenomics Reveals the Key Transcriptional Regulators of Human Antigen-Inducible Tregs |
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Ruby Lunde, Bristol Myers Squibb
Automated Analytical Pipeline for Cell Therapy Hypothesis Generation |
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Daniel P Caron, Columbia University Irving Medical Center
Multimodal Hierarchical Classification of CITE-Seq Data Enables Delineation of Tissue-Specific Signatures Shared Across Human Immune Cell Subsets |
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Aditya Murthy, Gilead Sciences
Decoding Regulators of Inflammatory Macrophage States Through Functional Genomics |
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Jishnu Das, University of Pittsburgh
Sliding Window Interaction Grammar (SWING) - a Generalized Interaction Language Model for Decoding Biological Interactions |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Programming and Engineering Immune Cells: Understand to Build and Build to Understand |
Van Horne B |
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Alex Marson, Gladstone Institutes, University of California, San Francisco
Genomics Programming of Human T Cells |
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Jenny McGovern, Quell Therapeutics
Regulatory T Cell Engineering |
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Mirco J Friedrich, MIT
Short Talk: Short Talk: Reprogramming T Cell Aging with a Transient mRNA Intervention |
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Yiming Yin, Boston Children's Hospital
Short Talk: Short Talk: Affinity Maturation of CRISPR-Engineered B-Cell Receptors in vivo |
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Nicholas Kalogriopoulos, Stanford University
Short Talk: Short Talk: Programmable Synthetic GPCRs for Customized Antigen-dependent Control of Cell Behaviors |
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Alissa Danford, UC Berkeley
Short Talk: Short Talk: Depletion of Intratumoral Tregs Enhances Tumor Immunity Locally and Systemically Against Disseminated Metastatic Cancer |
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| 7:00–8:00 PM |
Social Hour with Lite Bites |
President's Hall |
| 7:30–10:00 PM |
Poster Session 1 |
Van Horne C |
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
Immunoreceptors: Specificities, Interactions, and Engineering |
Van Horne B |
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Frederick A. Matsen IV, Fred Hutchinson Cancer Research Center
Deconvolving Mutation and Selection in Antibody Evolution using Neural Networks Trained on Large-Scale Repertoire Data |
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Armita Nourmohammad, University of Washington
Leaning the Shape of the Immune and Protein Universe |
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Stephanie A. Gaglione, Massachusetts Institute of Technology
Viruses for High-throughput Antigen Discovery |
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Mark Coles, University of Oxford
Short Talk: Short Talk: Combining Mechanistic Modelling with Machine Learning to Predict Human T Cell Epitopes and Vaccine Immune Responses in Ancestrally Diverse Populations |
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| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–1:00 PM |
Poster Setup |
Van Horne C |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 1:00–10:00 PM |
Poster Viewing |
Van Horne C |
| 3:00–4:30 PM |
Career Roundtable (Joint) |
Van Horne B |
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Sarah Teichmann, Wellcome Sanger Institute
Head of Cellular Genetics and Senior Group Leader, Co-Founder and Principal Leader of Human Cell Atlas |
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Kara Lassen, Roche
VP and Global Head, Immunology Therapeutic Area |
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Bryan D. Bryson, Massachusetts Institute of Technology
Associate Professor |
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Jonathan Sockolosky, Curie.Bio
Senior Director, CSO Partner Team |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–7:00 PM |
Immunoengineering and Drug Development |
Van Horne B |
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Christoph Bock, CeMM & Medical University of Vienna
Immune Cell Engineering and “Structural Immunity' |
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Caleb Perez, MIT
Mapping Diverse CAR Signaling Inputs to Transcriptional and Functional Outcomes via Library-Based Single-Cell Omics Assays |
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Kate Griffin, University of Michigan
Short Talk: Short Talk: Nanoparticles Reprogram Circulating Immune Cells to Alter the Metastatic Niche and Reduce Metastatic Burden in Murine Triple Negative Breast Cancer |
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Nathaniel Robichaud, Nomic Bio
Short Talk: Short Talk: High-Throughput Protein Profiling Captures Variability Across Donors, Cellular Environments, and Perturbations - Implications for Systems and Engineering Immunology |
|
| 7:00–8:00 PM |
Social Hour with Lite Bites |
President's Hall |
| 7:30–10:00 PM |
Poster Session 2 |
Van Horne C |
| 7:00–8:00 AM |
Breakfast |
President's Hall |
| 8:00–11:00 AM |
The Emerging, Unexpected and New Frontiers (Joint) |
Van Horne A |
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Sarah Teichmann, Wellcome Sanger Institute
What's Next in Human Cell Atlasing? |
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Graham Heimberg, Genentech, Inc.
SCimilarity Queries Reveal Connections across Macrophage Populations |
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Nicolas Chevrier, University of Chicago
Decoding the Body Language of Immunity |
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Subhajit Poddar, University of Pennsylvania
Short Talk: Short Talk: STING Modulates Golgi pH, Cargo Sorting, and Secretion Through ArfGAP2 |
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Toufic Mayassi, Broad Institute
Short Talk: Short Talk: Molecular Cartography Reveals Robust, Adaptable, and Resilient Intestinal Networks |
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Shubham Tripathi, Yale School of Medicine
Short Talk: Short Talk: Role of a Cellular Circuit Involving IFN-γ / IL-15 Positive Feedback in Establishing Antigen-Non-Specific Immune Memory |
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Tomer Milo, Weizmann Institute of Science
Short Talk: Short Talk: A Paradox of Foreign-Specific Regulatory T Cells and a Proposed Resolution by a Lymph Node Microdomain Theory |
|
| 9:00–9:20 AM |
Coffee Break |
Van Horne Foyer |
| 11:00–5:00 PM |
On Own for Lunch |
|
| 2:30–4:30 PM |
Workshop 2: In vivo Systems Immunology and Engineering: Emerging Areas and Challenges |
Van Horne B |
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Antonella Prisco, National Research Council (Italy)
Modeling Variations in Antibody Response Longevity Among Individuals |
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David R. Glass, Fred Hutchinson Cancer Center
Bridging the Identity and Function of Human Plasma Cell Subsets |
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Neil Tay, University of California, San Francisco
Tracking Cell-Cell Interactions Using Intercellular Barcode Transfer |
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Nicole Rosin, University of Calgary
A Systems Biology Approach to Understanding Wound Healing |
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Katherine Susa, UCSF
A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation |
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Catera L Wilder, University of California, San Francisco
Dynamic Control of Signaling Networks: Uncovering Specificity in Interferon-Mediated Cellular Responses Through Coordinated Positive Feedback Loops |
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| 4:30–5:00 PM |
Coffee Available |
Van Horne Foyer |
| 5:00–6:45 PM |
Tissue Systems Immunology and Dynamics |
Van Horne B |
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Shannon J Turley, Genentech, Inc.
Evolution of Stromal Niches in Inflammation, Cancer and Immunotherapy |
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Karin Pelka, Gladstone Institutes and University of California, San Francisco
Spatially Organized Immune Hubs in Human Tumors |
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Gabriel D. Victora, Rockefeller University
Multicellular Dynamics in Germinal Center Responses |
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Samuel Kazer, Boston Children's Hospital & Harvard Medical School
Short Talk: Short Talk: Primary Nasal Viral Infection Rewires the Tissue-Scale Memory Response |
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| 6:45–7:00 PM |
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) |
Van Horne B |
| 7:00–8:00 PM |
Social Hour with Lite Bites |
President's Hall |
| 8:00–9:00 PM |
Trivia! |
Van Horne A |
| 8:00–9:00 PM |
Cash Bar |
President's Hall |
