Neural-Immune Interactions: A Systems-Wide Perspective on Whole Organism Physiology (Z3)
June 8-11, 2025  | Whistler Conference Centre, Whistler, BC, Canada
Dorothy Schafer, Asya Rolls and Anne Schaefer
Scholarship Deadline: Mar. 26, 2025 | Abstract Deadline: May. 16, 2025 | Early Registration Deadline: Apr. 23, 2025
* Session Chair † Invited but not yet accepted | Program current as of August 23, 2025 4 AM | For the most up-to-date details, visit https://www.keystonesymposia.org
Sunday, June 8, 2025
4:00–8:00 PM Registration Grand Foyer
6:00–8:00 PM Welcome Mixer Grand Foyer
Monday, June 9, 2025
7:00–8:00 AM Breakfast Sea to Sky A
8:00–9:30 AM Welcome and Keynote Session (Joint) Sea to Sky B/C
  * Dorothy Schafer, University of Massachusetts Chan Medical School
 
  Catherine G. Dulac, Harvard University and HHMI
Neuronal Circuits of Sickness and Social Behavior
 
  Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT
Development of Epigenetic Modifiers for Discovery Research and Neurodegenerative Disease Therapies
 
9:30–9:50 AM Coffee Break Grand Foyer
9:50–11:30 AM Cell Biology of Neuroinflammation within Diseased Brain Circuits (Joint) Sea to Sky B/C
  * Richard Daneman, University of California, San Diego
Session Chair
 
  Veronique Miron, University of Toronto
Accumulation of dysfunctional oligodendrocytes in human cognitive decline with aging
 
  Timothy Hammond, Sanofi
Therapeutic Targeting of Microglial Inflammatory Responses within Diseased Brain Circuits
 
  Aaron DiAntonio, Washington University in St. Louis
The SARM1 Axon Degeneration Pathway: Mechanistic Insights Drive Therapeutic Opportunities
 
11:15–1:00 PM Poster Setup Sea to Sky A
11:15–2:30 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Sea to Sky A
2:30–4:30 PM Symposia Spotlight 1: The Digital Era in Neurodegeneration and Neuroinflammation & Panel Discussion(Joint) Sea to Sky B/C
  * Michael Ward, NIH
Session Chair
 
  Max Salick, Insitro
Integrating iPSC-Based Models, Genomics, And Machine Learning To Uncover Neurological Disease Mechanisms And Therapeutic Targets
 
  Camille Januel, Chan Zuckerberg Biohub San Francisco
Global Organelle Profiling: Combining Stem Cell Models and Proteomics to Uncover Variant-Specific Disease Mechanism in Neurodegenerative Diseases
 
  Heather Stark, Syncell
Optoproteomics: Unbiased Spatial Proteomics for Neurodegenerative Diseases
 
  Carmen Sandoval-Espinosa, Genentech
Soma-seq: Intracellular CITE-seq in Frozen Human Brain Tissue Enables the Discovery of Proteinopathy-Associated Gene Expression Signatures
 
  Zinan Zhou, Boston Children's Hospital
Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders
 
4:30–5:00 PM Coffee Available Grand Foyer
5:00–7:00 PM Neural-Immune Signaling Intrinsic to Brain Circuits Sea to Sky B
  * Veronique Miron, University of Toronto
Session Chair
 
  Anne Schaefer, Icahn School of Medicine at Mount Sinai, MPI Ageing
Alzheimer’s Disease Reveals Regulatory Microglia Potential
 
  Ádám Dénes, Hungarian Academy of Sciences
Microglia Control Circuit Homeostasis and Pathological States
 
  Richard Daneman, University of California, San Diego
The Brain Vasculature: A Conduit between the Periphery and Control of Brain Circuits
 
  Baljit S. Khakh, David Geffen School of Medicine, UCLA
Astrocyte Control of Neural Circuits During Inflammation
 
7:00–8:00 PM Social Hour with Lite Bites Sea to Sky A
7:30–10:00 PM Poster Session 1 Sea to Sky A
Tuesday, June 10, 2025
7:00–8:00 AM Breakfast Sea to Sky A
8:00–11:00 AM Mechanisms of Aging in Neuroinflammation and Neurodegeneration (Joint) Sea to Sky B/C
  * John Fryer, Translational Genomics Research Institute
Session Chair
 
  Robin Franklin, Altos Labs
The Impact of Aging on Remyelination Potential in the Inflamed Brain
 
  Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
Role of cGAS/Sting in Neurodegenerative Diseases
 
  Judith Frydman, Stanford University
Age-Related Translational and Ribosomal Dysfunction and its Contribution to Neurodegeneration
 
  Oliver Hahn, Calico Life Sciences LLC
Short Talk: Decoding Regional Drivers of Microglia Aging via Heterochronic Myeloid Cell Replacement
 
  Ian Guldner, Stanford University
Short Talk: Synaptic Proteins with Age-Related Proteostasis Aberrations Accumulate in Microglia
 
  Vanessa Martin, University of California, San Diego
Short Talk: Enhancer Deletion of a Microglial-Specific AD BIN1 Risk Variant Alters Lysosomal Phenotype and DAM Response in Ipsc-Derived Microglia
 
  Wei Jing Chong, Nanyang Technological University
Short Talk: Targeting Cellular Metabolism to Modulate Microglial Function in Health and Disease
 
9:00–9:20 AM Coffee Break Grand Foyer
9:20–9:25 AM Award Recipient Acknowledgement Sea to Sky B/C
11:00–1:00 PM Poster Setup Sea to Sky A
11:00–3:30 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Sea to Sky A
2:15–3:15 PM Career Roundtable (Joint) Sea to Sky B
  Maayan Levy, Stanford University
Assistant Professor
 
  Alessandro Ori, Genentech Inc.
Senior Principal Scientist
 
  Dirk Landgraf, SV Health Investors
Principal, Dementia Discovery Fund
 
  Heather B Wood, Springer Nature
Senior Editor
 
3:30–4:30 PM Meet the Editors (Joint) Sea to Sky B
  Ted Dobie, Cell Press
*Session Chair, Scientific Editor, Neuron
 
  Shari Wiseman, Nature Neuroscience
Chief Editor
 
  Lucie Van Emmenis, The Rockefeller University Press - The Journal of Experimental Medicine
Senior Scientific Editor
 
  Eric Sawey, Genes & Development
Executive Editor, CSHL Press
 
  Taylor Hart, PLOS
Associate Editor
 
4:30–5:00 PM Coffee Available Grand Foyer
5:00–7:00 PM Neural Circuit Control of Immunity Sea to Sky B
  * Timothy Hammond, Sanofi
Session Chair
 
  Asya Rolls, Tel Aviv University
Immunoception- Neuronal Representation of Immune Processes to Modulate Behavior
 
  Erica K Sloan, Monash University
Stress-Induced Regulation of Immune System Function
 
  Isaac Chiu, Harvard Medical School
Neural Control of the Peripheral Immune Response
 
  Michelle Swarovski, University of Utah
Short Talk: Uncovering the Role of Circumventricular Organs During Infection
 
7:00–8:00 PM Social Hour with Lite Bites Sea to Sky A
7:30–10:00 PM Poster Session 2 Sea to Sky A
Wednesday, June 11, 2025
7:00–8:00 AM Breakfast Sea to Sky A
8:00–11:00 AM Neural-Immune Regulation of Peripheral Organ Homeostasis Sea to Sky B
  * Jonathan Kipnis, Washington University School of Medicine
Session Chair
 
  Jens C. Brüning, Max Planck Institute for Metabolism Research
Neural Control of Age-Related Metabolic Dysfunction
 
  Wenfei Han, Max Planck Institute for Biological Cybernetics
Neural Networks Controlling Peripheral Organ Function
 
  Ana Domingos, University of Oxford
Neuroimmune Control of Obesity
 
  Kartik Rajagopalan, UT Southwestern Medical Center
Short Talk: Leptin Signaling Maintains Autonomic Stability During Severe Influenza Infection in Mice
 
  Jaewon Sim, Michigan State University
Short Talk: Monocyte-derived IL-10 Drives Sex Difference in Pain Duration
 
  Caroline L Wee, A*STAR Institute of Molecular and Cell Biology
Short Talk: A Gut-Immune-Brain Circuit Links Diet-Induced Microbial Dysbiosis to Sleep Disruption
 
9:00–9:20 AM Coffee Break Grand Foyer
11:00–2:30 PM On Own for Lunch
2:30–4:30 PM Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions Sea to Sky B
  * Shelly Buffington, Baylor College of Medicine
Session Chair
 
  Nannan Lu, Stanford University
Remote Presenter: Exploring the Interaction between Blood Plasma Proteins and Microglia: Insights into Brain-Peripheral Communication
 
  Sravya Kurapati, University of Massachusetts Chan Medical School
Remote Presenter: Monocytes Mobilized by Enteric Neurons Remodel the Enteric Nervous System
 
  Mitre Athaiya, University of Michigan
Remote Presenter: The Role of Macrophage Metabolic Reprogramming in Peripheral Nervous System Regeneration and Development of Neuropathic Pain
 
  Irene Sanchez Martin, Cold Spring Harbor Laboratory
Remote Presenter: Maternal Immune Activation Reveals Male-Specific Sensitivity to Inflammation-Driven Deficits in Fetal Development
 
  Annie Ciernia, University of British Columbia
Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Microglia Axis
 
  Abi G Yates, Icahn School of Medicine at Mount Sinai
Astrocyte Precursor Cells Instruct Microglial Programming Via IL-3 For Neuronal Sculpting And Social Development
 
  Ugur Akcan, Columbia University
The Transcription Factor RXRɑ, Regulates the Disease-Associated Gene Signatures of Myeloid Cells in Immune-Mediated OCD
 
  Bradley J Cutler, The Ohio State University
Neuro-Immune Signaling Underlying Behavioral Fever in Larval Zebrafish
 
4:30–5:00 PM Coffee Available Grand Foyer
5:00–6:45 PM Immune System Control of Behavior Sea to Sky B
  * Isaac Chiu, Harvard Medical School
Session Chair
 
  Dorothy Schafer, University of Massachusetts Chan Medical School
Neural-Immune Signaling Governing Microglia Function Within Brain Circuits
 
  Maayan Levy, Stanford University
Understanding the Bi-Directional Communication Between the Gut and the Brain
 
  Jonathan Kipnis, Washington University School of Medicine
Immune Environment in Brain Borders Governing Circuit Function and Behavior
 
  Shelly Buffington, Baylor College of Medicine
Short Talk: Protozoan Parasite Disrupts Intestinal Immunity in Pregnancy, Thalamocortical Activity in Offspring
 
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Sea to Sky B
7:00–8:00 PM Social Hour with Lite Bites Sea to Sky A
8:00–9:00 PM Entertainment Sea to Sky C
Thursday, June 12, 2025
12:00–11:59 PM Departure