4:00–8:00 PM | Registration | Grand Foyer |
6:00–8:00 PM | Welcome Mixer | Grand Foyer |
7:00–8:00 AM | Breakfast | Sea to Sky A |
8:00–9:30 AM | Welcome and Keynote Session (Joint) | Sea to Sky B/C |
* Dorothy Schafer, University of Massachusetts Chan Medical School |
Catherine G. Dulac, Harvard University and HHMI Neuronal Circuits of Sickness and Social Behavior |
Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT Development of Epigenetic Modifiers for Discovery Research and Neurodegenerative Disease Therapies |
9:30–9:50 AM | Coffee Break | Grand Foyer |
9:50–11:30 AM | Cell Biology of Neuroinflammation within Diseased Brain Circuits (Joint) | Sea to Sky B/C |
* Richard Daneman, University of California, San Diego Session Chair |
Veronique Miron, University of Toronto Accumulation of dysfunctional oligodendrocytes in human cognitive decline with aging |
Timothy Hammond, Sanofi Therapeutic Targeting of Microglial Inflammatory Responses within Diseased Brain Circuits |
Aaron DiAntonio, Washington University in St. Louis The SARM1 Axon Degeneration Pathway: Mechanistic Insights Drive Therapeutic Opportunities |
11:15–1:00 PM | Poster Setup | Sea to Sky A |
11:15–2:30 PM | On Own for Lunch |
1:00–10:00 PM | Poster Viewing | Sea to Sky A |
2:30–4:30 PM | Symposia Spotlight 1: The Digital Era in Neurodegeneration and Neuroinflammation & Panel Discussion(Joint) | Sea to Sky B/C |
* Michael Ward, NIH Session Chair |
Max Salick, Insitro Integrating iPSC-Based Models, Genomics, And Machine Learning To Uncover Neurological Disease Mechanisms And Therapeutic Targets |
Camille Januel, Chan Zuckerberg Biohub San Francisco Global Organelle Profiling: Combining Stem Cell Models and Proteomics to Uncover Variant-Specific Disease Mechanism in Neurodegenerative Diseases |
Heather Stark, Syncell Optoproteomics: Unbiased Spatial Proteomics for Neurodegenerative Diseases |
Carmen Sandoval-Espinosa, Genentech Soma-seq: Intracellular CITE-seq in Frozen Human Brain Tissue Enables the Discovery of Proteinopathy-Associated Gene Expression Signatures |
Zinan Zhou, Boston Children's Hospital Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders |
4:30–5:00 PM | Coffee Available | Grand Foyer |
5:00–7:00 PM | Neural-Immune Signaling Intrinsic to Brain Circuits | Sea to Sky B |
* Veronique Miron, University of Toronto Session Chair |
Anne Schaefer, Icahn School of Medicine at Mount Sinai, MPI Ageing Alzheimer’s Disease Reveals Regulatory Microglia Potential |
Ádám Dénes, Hungarian Academy of Sciences Microglia Control Circuit Homeostasis and Pathological States |
Richard Daneman, University of California, San Diego The Brain Vasculature: A Conduit between the Periphery and Control of Brain Circuits |
Baljit S. Khakh, David Geffen School of Medicine, UCLA Astrocyte Control of Neural Circuits During Inflammation |
7:00–8:00 PM | Social Hour with Lite Bites | Sea to Sky A |
7:30–10:00 PM | Poster Session 1 | Sea to Sky A |
7:00–8:00 AM | Breakfast | Sea to Sky A |
8:00–11:00 AM | Mechanisms of Aging in Neuroinflammation and Neurodegeneration (Joint) | Sea to Sky B/C |
* John Fryer, Translational Genomics Research Institute Session Chair |
Robin Franklin, Altos Labs The Impact of Aging on Remyelination Potential in the Inflamed Brain |
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne Role of cGAS/Sting in Neurodegenerative Diseases |
Judith Frydman, Stanford University Age-Related Translational and Ribosomal Dysfunction and its Contribution to Neurodegeneration |
Oliver Hahn, Calico Life Sciences LLC Short Talk: Decoding Regional Drivers of Microglia Aging via Heterochronic Myeloid Cell Replacement |
Ian Guldner, Stanford University Short Talk: Synaptic Proteins with Age-Related Proteostasis Aberrations Accumulate in Microglia |
Vanessa Martin, University of California, San Diego Short Talk: Enhancer Deletion of a Microglial-Specific AD BIN1 Risk Variant Alters Lysosomal Phenotype and DAM Response in Ipsc-Derived Microglia |
Wei Jing Chong, Nanyang Technological University Short Talk: Targeting Cellular Metabolism to Modulate Microglial Function in Health and Disease |
9:00–9:20 AM | Coffee Break | Grand Foyer |
9:20–9:25 AM | Award Recipient Acknowledgement | Sea to Sky B/C |
11:00–1:00 PM | Poster Setup | Sea to Sky A |
11:00–3:30 PM | On Own for Lunch |
1:00–10:00 PM | Poster Viewing | Sea to Sky A |
2:15–3:15 PM | Career Roundtable (Joint) | Sea to Sky B |
Maayan Levy, Stanford University Assistant Professor |
Alessandro Ori, Genentech Inc. Senior Principal Scientist |
Dirk Landgraf, SV Health Investors Principal, Dementia Discovery Fund |
Heather B Wood, Springer Nature Senior Editor |
3:30–4:30 PM | Meet the Editors (Joint) | Sea to Sky B |
Ted Dobie, Cell Press *Session Chair, Scientific Editor, Neuron |
Shari Wiseman, Nature Neuroscience Chief Editor |
Lucie Van Emmenis, The Rockefeller University Press - The Journal of Experimental Medicine Senior Scientific Editor |
Eric Sawey, Genes & Development Executive Editor, CSHL Press |
Taylor Hart, PLOS Associate Editor |
4:30–5:00 PM | Coffee Available | Grand Foyer |
5:00–7:00 PM | Neural Circuit Control of Immunity | Sea to Sky B |
* Timothy Hammond, Sanofi Session Chair |
Asya Rolls, Tel Aviv University Immunoception- Neuronal Representation of Immune Processes to Modulate Behavior |
Erica K Sloan, Monash University Stress-Induced Regulation of Immune System Function |
Isaac Chiu, Harvard Medical School Neural Control of the Peripheral Immune Response |
Michelle Swarovski, University of Utah Short Talk: Uncovering the Role of Circumventricular Organs During Infection |
7:00–8:00 PM | Social Hour with Lite Bites | Sea to Sky A |
7:30–10:00 PM | Poster Session 2 | Sea to Sky A |
7:00–8:00 AM | Breakfast | Sea to Sky A |
8:00–11:00 AM | Neural-Immune Regulation of Peripheral Organ Homeostasis | Sea to Sky B |
* Jonathan Kipnis, Washington University School of Medicine Session Chair |
Jens C. Brüning, Max Planck Institute for Metabolism Research Neural Control of Age-Related Metabolic Dysfunction |
Wenfei Han, Max Planck Institute for Biological Cybernetics Neural Networks Controlling Peripheral Organ Function |
Ana Domingos, University of Oxford Neuroimmune Control of Obesity |
Kartik Rajagopalan, UT Southwestern Medical Center Short Talk: Leptin Signaling Maintains Autonomic Stability During Severe Influenza Infection in Mice |
Jaewon Sim, Michigan State University Short Talk: Monocyte-derived IL-10 Drives Sex Difference in Pain Duration |
Caroline L Wee, A*STAR Institute of Molecular and Cell Biology Short Talk: A Gut-Immune-Brain Circuit Links Diet-Induced Microbial Dysbiosis to Sleep Disruption |
9:00–9:20 AM | Coffee Break | Grand Foyer |
11:00–2:30 PM | On Own for Lunch |
2:30–4:30 PM | Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions | Sea to Sky B |
* Shelly Buffington, Baylor College of Medicine Session Chair |
Nannan Lu, Stanford University Remote Presenter: Exploring the Interaction between Blood Plasma Proteins and Microglia: Insights into Brain-Peripheral Communication |
Sravya Kurapati, University of Massachusetts Chan Medical School Remote Presenter: Monocytes Mobilized by Enteric Neurons Remodel the Enteric Nervous System |
Mitre Athaiya, University of Michigan Remote Presenter: The Role of Macrophage Metabolic Reprogramming in Peripheral Nervous System Regeneration and Development of Neuropathic Pain |
Irene Sanchez Martin, Cold Spring Harbor Laboratory Remote Presenter: Maternal Immune Activation Reveals Male-Specific Sensitivity to Inflammation-Driven Deficits in Fetal Development |
Annie Ciernia, University of British Columbia Early-Life Gut Inflammation Drives Sex-Dependent Shifts in the Microbiome-Endocrine-Microglia Axis |
Abi G Yates, Icahn School of Medicine at Mount Sinai Astrocyte Precursor Cells Instruct Microglial Programming Via IL-3 For Neuronal Sculpting And Social Development |
Ugur Akcan, Columbia University The Transcription Factor RXRɑ, Regulates the Disease-Associated Gene Signatures of Myeloid Cells in Immune-Mediated OCD |
Bradley J Cutler, The Ohio State University Neuro-Immune Signaling Underlying Behavioral Fever in Larval Zebrafish |
4:30–5:00 PM | Coffee Available | Grand Foyer |
5:00–6:45 PM | Immune System Control of Behavior | Sea to Sky B |
* Isaac Chiu, Harvard Medical School Session Chair |
Dorothy Schafer, University of Massachusetts Chan Medical School Neural-Immune Signaling Governing Microglia Function Within Brain Circuits |
Maayan Levy, Stanford University Understanding the Bi-Directional Communication Between the Gut and the Brain |
Jonathan Kipnis, Washington University School of Medicine Immune Environment in Brain Borders Governing Circuit Function and Behavior |
Shelly Buffington, Baylor College of Medicine Short Talk: Protozoan Parasite Disrupts Intestinal Immunity in Pregnancy, Thalamocortical Activity in Offspring |
6:45–7:00 PM | Meeting Wrap-Up: Outcomes and Future Directions (Organizers) | Sea to Sky B |
7:00–8:00 PM | Social Hour with Lite Bites | Sea to Sky A |
8:00–9:00 PM | Entertainment | Sea to Sky C |
12:00–11:59 PM | Departure |