Neuroimmune Interactions: Nervous System and Immune Cell Heterogeneity in Health and Disease (Z4)
June 3-6, 2024  | Santa Fe Community Convention Center, Santa Fe, NM, United States
Nicola J. Allen, Anna Victoria Molofsky and Francisco J. Quintana
Scholarship Deadline: Feb. 29, 2024 | Abstract Deadline: Feb. 29, 2024 | Early Registration Deadline: Apr. 4, 2024
* Session Chair † Invited but not yet accepted | Program current as of November 4, 2025 2 PM | For the most up-to-date details, visit https://www.keystonesymposia.org
Monday, June 3, 2024
4:00–8:00 PM Arrival and Registration Sweeney Ballroom Foyer
6:00–8:00 PM Welcome Mixer Lobby
Tuesday, June 4, 2024
7:00–8:00 AM Breakfast Sweeney F, Main Level Breakouts
7:30–8:00 AM Poster Setup Sweeney Ballroom F
8:00–9:30 AM Welcome and Keynote Session (Joint) Sweeney Ballroom A-E
  Tony Wyss-Coray, Stanford University School of Medicine
Aging, the Immune System and Neurodegeneration		  
  Beth Stevens, Boston Children's Hospital, Harvard Medical School
Connecting Human Microglia States to Function in Health and Disease		  
8:00–7:00 PM Poster Viewing Sweeney Ballroom F
9:30–9:50 AM Coffee Break Sweeney Ballroom Foyer
9:50–11:15 AM Immune-CNS Interactions in Neurodegeneration (Joint) Sweeney Ballroom A-E
  Christopher K. Glass, University of California, San Diego
Transcriptional Regulation of Macrophage Development		  
  S. Pablo Sardi, Sanofi
Therapeutic Development for Neurodegenerative Disorders		  
  Anne Schaefer, Icahn School of Medicine at Mount Sinai, MPI Ageing
Epigenetic Regulation of Microglia		  
11:15–12:15 PM Lunch Sweeney F, Main Level Breakouts
11:45–2:30 PM Poster Session 1 Sweeney Ballroom F
2:30–4:30 PM Workshop 1: Communication Across Brain Barriers Sweeney Ballroom C-E
  Miguel MarinRodero, Harvard Medical School
The Meninges Host a Unique Compartment of Regulatory T Cells That Bulwarks Adult Hippocampal Neurogenesis		  
  Nagela Ghabdan Zanluqui, National Institutes of Health
Venous Plexus-Associated Lymphoid Hubs Support Meningeal Humoral Immunity		  
  Nannan Lu, Stanford University
Exploring the Interaction Between Blood Plasma Proteins and Microglia: Insights into Brain-Peripheral Communication		  
  Amy Joy Dashwood, University of Cambridge
Novel Genetic Systems Show Feedback from CD4 T Cell Infiltrate in Aged Mouse Brain Shapes and Selects Microglia Populations		  
  Helena Barr, Harvard University | Boston Children's Hospital
Diurnal Regulation of Brain Border Macrophage Phenotype and Function Across the Lifespan		  
  Lara Labarta-Bajo, Salk Institute for Biological Studies
Investigating a Role for Astrocyte Stat1 in the Aged Brain		  
  Brittany M Hemmer, Icahn School of Medicine at Mount Sinai
Youth-Associated Plasma Protein TIMP2 Regulates Microglial State in the Context of Aging and Alzheimer’s Pathology		  
4:30–5:00 PM Coffee Available Sweeney Ballroom Foyer
5:00–7:00 PM Sterile and Pathogen-Mediated Brain Injury Sweeney Ballroom C-E
  Robyn S Klein, Western University, London, Ontario
Impact of Viral Infection on CNS Function		  
  William H. Robinson, Stanford University School of Medicine
The Role of EBV in Multiple Sclerosis		  
  Thomas Korn, Technical University Munich
A Fresh Look at B Cells in Neuromyelitis Optica		  
  Min Woo Kim, Washington University in St. Louis
Short Talk: The Immunopeptidome of the CNS Reveals Endogenous Peptides that Guard against Autoimmunity		  
  Zeynep Ilgin Kolabas, Helmholtz Munich
Short Talk: Short Talk: Decoding the Neuroimmune Interface: Unique Molecular Insights from Skull Bone Marrow in Health and Disease		  
7:00–8:00 PM On Own for Dinner
Wednesday, June 5, 2024
7:00–8:00 AM Breakfast Sweeney F, Main Level Breakouts
8:00–11:00 AM Glial-Immune Interactions Sweeney Ballroom C-E
  Anna Victoria Molofsky, University of California, San Francisco
Cytokines in CNS Development		  
  Francisco J. Quintana, Harvard Medical School and the Broad Institute of MIT and Harvard
Astrocytes and Inflammatory Signaling		  
  Nicola J. Allen, The Salk Institute for Biological Studies
Astrocyte-Neuron Interactions in Aging and Neurodegeneration		  
  Naomi Habib, Hebrew University of Jerusalem
Reconstruction of Multi-Cellular Dynamics Underlying Aging and Alzheimer's Disease: One Cell at a Time		  
  Kristine Zengeler, University of Virginia
Short Talk: Short Talk: Astrocyte Inflammasome Signaling Modulates Synaptic Plasticity		  
  Stefan Bittner, University Medical Center Mainz, Germany
Short Talk: Short Talk: TRPA1 Channels Control Central Nervous System Inflammation via MHC Class II Modulation on Astrocytes		  
9:00–9:20 AM Coffee Break Sweeney Ballroom Foyer
11:00–1:00 PM Poster Setup Sweeney Ballroom F
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Sweeney Ballroom F
2:30–4:30 PM Career Roundtable (Joint) Sweeney Ballroom C-E
  Francesca Odoardi, University Medical Center Göttingen
Group Leader & Professor		  
  Suman Jayadev, University of Washington
Associate Professor, Director and Neurogeneticist		  
  Arya Biragyn, NIA, National Institutes of Health
Senior Investigator		  
  Sarah DeVos, Curie.Bio
Drug Maker in Residence		  
  Tim Spencer, Journal of Cell Biology
Executive Editor		  
4:30–5:00 PM Coffee Available Sweeney Ballroom Foyer
5:00–7:00 PM Immune Regulation of Behavior Sweeney Ballroom C-E
  Jessica Osterhout, University of Utah School of Medicine
Immune Regulation of Social Behavior		  
  Helen Vuong, University of Minnesota, Twin Cities
Maternal Microbiome Regulation of Fetal Development and Sensory Behaviors		  
  Marco Prinz, University of Freiburg
Innate Immune Cells at Human CNS Borders Mapped across Space, Time and Perturbation		  
  Anna Geraghty, Stanford University
Short Talk: Short Talk: Immunotherapy-Related Cognitive Impairment After CAR T Cell Therapy in Mice		  
7:00–8:00 PM Social Hour with Lite Bites Sweeney F, Main Level Breakouts
7:30–10:00 PM Poster Session 2 Sweeney Ballroom F
Thursday, June 6, 2024
7:00–8:00 AM Breakfast Sweeney F, Main Level Breakouts
8:00–11:00 AM Peripheral Immune Signaling and Impact on Neural Circuits Sweeney Ballroom C-E
  Francesca Odoardi, University Medical Center Göttingen
Lung Microbiome Regulation of Brain Autoimmunity		  
  Michael D. Burton, University of Texas at Dallas
Neuroimmune Regulation of Pain and Depression		  
  Scott J. Russo, Icahn School of Medicine at Mount Sinai
Immune-brain Interactions in Stress and Depression		  
  Anna-Maria Globig, Salk Institute for Biological Studies
Short Talk: Short Talk: Sympathetic Nerves Instruct T Cell Exhaustion in Viral Infection and Cancer via the Noradrenaline Receptor ADRB1		  
  Elizabeth Balint, McMaster University
Short Talk: Short Talk: Bystander Activated CD8+ T Cells Mediate Neuropathology During Viral Infection via Antigen-Independent Cytotoxicity		  
  Yangyang Zhu, Harvard Medical School
Short Talk: Short Talk: A Chemogenetic Screen for Neuroimmune Interplay Reveals Trpv1+ Neuron Control of Tregs in the Gut		  
  Timothy Cox, University of Pennsylvania
Short Talk: Short Talk: Microbiome Regulation of Age-Associated Cognitive Decline		  
9:00–9:20 AM Coffee Break Sweeney Ballroom Foyer
11:00–1:00 PM Poster Setup Sweeney Ballroom F
11:00–5:00 PM On Own for Lunch
1:00–10:00 PM Poster Viewing Sweeney Ballroom F
2:30–4:30 PM Workshop 2: Neuroinflammation in Aging and Disease Sweeney Ballroom C-E
  Genevieve Curtin, UCSD
Microglia, Macroproblems: Cellular Dysfunction in Microglia Derived from Down Syndrome Patients		  
  Yingying Zhang, Boston Children's Hospital
Spatial and Temporal Profiling of the Complement System Uncovered Novel Functions of the Alternative Complement Pathway in Brain Development		  
  Sean Ryan, Sanofi
Ferroptosis Activation in Multiple Sclerosis		  
  Gerard E. Crowley, University College London
Innate-Adaptive Immune Crosstalk Regulates Activity-Dependent Synapse Loss		  
  Qihui Zhou, German Center for Neurodegenerative Diseases
Microglia Mediated CD3+ T cell Accumulation Facilitate Neurodegeneration in C9orf72 ALS Mice		  
  Christina Mayer, University Medical Center Hamburg-Eppendorf
Complement Factor H Protects Against Neuronal Ferroptosis in Multiple Sclerosis		  
  Anna Flury, CUNY Graduate Center
A Conserved Stress Response Associated with Dark Microglia Drives Neurodegeneration in Alzheimer’s Disease		  
4:30–5:00 PM Coffee Available Sweeney Ballroom Foyer
5:00–6:45 PM Microglia Function Sweeney Ballroom C-E
  Takahiro Masuda, Kyushu University
Targeting Microglia for Genetic Manipulation		  
  Borislav Dejanovic, Vigil Neuroscience
Unlocking the Potential of TREM2: VG-3927 as a Novel Therapeutic for Alzheimer’s Disease		  
  Long-Jun Wu, University of Texas Health Science Center
Short Talk: Short Talk: Microglia Promote Neuronal Activity via Shielding Inhibitory Synapses		  
  Wangchao Xu, Washington University in St. Louis
Short Talk: Short Talk: A Microbe-Neuroendocrine- Immune Axis in Health, Aging, and Infection		  
  Hayley Strasburger, Icahn School of Medicine at Mount Sinai
Short Talk: Short Talk:Dopamine-Mediated Control of Microglia-Neuron Interaction and Function		  
6:45–7:00 PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Sweeney Ballroom C-E
7:00–8:00 PM Social Hour with Lite Bites Sweeney F, Main Level Breakouts
7:30–10:00 PM Poster Session 3 Sweeney Ballroom F
Friday, June 7, 2024
7:00–11:59 PM Departure