| 4:00–8:00 PM | Registration | Grand Foyer |
| 6:00–8:00 PM | Welcome Mixer | Grand Foyer |
| 7:00–8:00 AM | Breakfast | Sea to Sky A |
| 8:00–9:30 AM | Welcome and Keynote Session (Joint) | Sea to Sky B/C |
| * Dorothy Schafer, University of Massachusetts Chan Medical School |
| Catherine G. Dulac, Harvard University and HHMI Neuronal Circuits of Sickness and Social Behavior |
| Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT Development of Epigenetic Modifiers for Discovery Research and Neurodegenerative Disease Therapies |
| 9:30–9:50 AM | Coffee Break | Grand Foyer |
| 9:50–11:30 AM | Cell Biology of Neuroinflammation Within Diseased Brain Circuits (Joint) | Sea to Sky B/C |
| * Richard Daneman, University of California, San Diego Session Chair |
| Veronique Miron, University of Toronto Immune Regulation of Remyelination in Multiple Sclerosis |
| Timothy Hammond, Sanofi Therapeutic Targeting of Microglial Inflammatory Responses within Diseased Brain Circuits |
| Aaron DiAntonio, Washington University in St. Louis The SARM1 Axon Degeneration Pathway: Mechanistic Insights Drive Therapeutic Opportunities |
| 11:15–1:00 PM | Poster Setup | Sea to Sky A |
| 11:15–2:30 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Sea to Sky A |
| 2:30–4:30 PM | Symposia Spotlight 1: The Digital Era in Neurodegeneration and Neuroinflammation & Panel Discussion(Joint) | Sea to Sky B/C |
| * Michael Ward, NIH Session Chair |
| Max Salick, Insitro Integrating iPSC-Based Models, Genomics, And Machine Learning To Uncover Neurological Disease Mechanisms And Therapeutic Targets |
| Camille Januel, Chan Zuckerberg Biohub San Francisco Global Organelle Profiling: Combining Stem Cell Models and Proteomics to Uncover Variant-Specific Disease Mechanism in Neurodegenerative Diseases |
| Heather Stark, Syncell Optoproteomics: Unbiased Spatial Proteomics for Neurodegenerative Diseases |
| Carmen Sandoval-Espinosa, Genentech Soma-seq: Intracellular CITE-seq in Frozen Human Brain Tissue Enables the Discovery of Proteinopathy-Associated Gene Expression Signatures |
| Zinan Zhou, Boston Children's Hospital Recurrent Patterns of Widespread Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders |
| 4:30–5:00 PM | Coffee Available | Grand Foyer |
| 5:00–7:00 PM | Genetics and Genomics in Neurodegeneration | Sea to Sky C |
| * Thomas L. Kukar, Emory University Session Chair |
| Juliana Acosta-Uribe, University of California, Santa Barbara Ancestral Diversity in Neurodegenerative Disease Genomics |
| Alison Goate, Icahn School of Medicine at Mount Sinai Genetics and Genomics of Alzheimer’s Disease |
| Azad Bonni, F.Hoffmann La-Roche Ltd. Challenges and Opportunities in Drug Discovery and Development for Neurological Disorders |
| Lindsay Becker, Princeton University Short Talk: Genome-Wide Mapping of Neuronal RNA Organization and Condensation |
| Alessandro Ori, Genentech Inc. Short Talk: Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder |
| 7:00–8:00 PM | Social Hour with Lite Bites | Sea to Sky A |
| 7:30–10:00 PM | Poster Session 1 | Sea to Sky A |
| 7:00–8:00 AM | Breakfast | Sea to Sky A |
| 8:00–11:00 AM | Mechanisms of Aging in Neuroinflammation and Neurodegeneration (Joint) | Sea to Sky B/C |
| * John Fryer, Translational Genomics Research Institute Session Chair |
| Robin Franklin, Altos Labs The Impact of Aging on Remyelination Potential in the Diseased Brain |
| Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne Role of cGAS/Sting in Neurodegenerative Diseases |
| Judith Frydman, Stanford University Age-Related Translational and Ribosomal Dysfunction and its Contribution to Neurodegeneration |
| Oliver Hahn, Calico Life Sciences LLC Short Talk: Decoding Regional Drivers of Microglia Aging via Heterochronic Myeloid Cell Replacement |
| Ian Guldner, Stanford University Short Talk: Synaptic Proteins with Age-Related Proteostasis Aberrations Accumulate in Microglia |
| Vanessa Martin, University of California, San Diego Short Talk: Enhancer Deletion of a Microglial-Specific AD BIN1 Risk Variant Alters Lysosomal Phenotype and DAM Response in Ipsc-Derived Microglia |
| Wei Jing Chong, Nanyang Technological University Short Talk: Targeting Cellular Metabolism to Modulate Microglial Function in Health and Disease |
| 9:00–9:20 AM | Coffee Break | Grand Foyer |
| 9:20–9:25 AM | Award Recipient Acknowledgement | Sea to Sky B/C |
| 11:00–1:00 PM | Poster Setup | Sea to Sky A |
| 11:00–5:00 PM | On Own for Lunch |
| 1:00–10:00 PM | Poster Viewing | Sea to Sky A |
| 2:15–3:15 PM | Career Roundtable (Joint) | Sea to Sky B |
| Maayan Levy, Stanford University Assistant Professor |
| Alessandro Ori, Genentech Inc. Senior Principal Scientist |
| Dirk Landgraf, SV Health Investors Principal, Dementia Discovery Fund |
| Heather B Wood, Springer Nature Senior Editor |
| 3:30–4:30 PM | Meet the Editors (Joint) | Sea to Sky B |
| Ted Dobie, Cell Press *Session Chair, Scientific Editor, Neuron |
| Shari Wiseman, Nature Neuroscience Chief Editor |
| Lucie Van Emmenis, The Rockefeller University Press - The Journal of Experimental Medicine Senior Scientific Editor |
| Eric Sawey, Genes & Development Executive Editor, CSHL Press |
| Taylor Hart, PLOS Associate Editor |
| 4:30–5:00 PM | Coffee Available | Grand Foyer |
| 5:00–7:00 PM | Critical Cellular Pathways in Neurodegeneration | Sea to Sky C |
| * Sandrine Da Cruz, VIB-KU Leuven Session Chair |
| Erika L Holzbaur, University of Pennsylvania Organelle Quality Control in Neuronal Homeostasis and Neurodegeneration. |
| Juan S. Bonifacino, National Institutes of Health Role of Lysosomes in the Axon in Health vs. Diseased Neurons |
| Dario Alessi, University of Dundee Mechanisms of LRRK2 Related Neurodegeneration |
| Amanda Bentley-DeSousa, Yale University Short Talk: Integration of Innate Immunity and Lysosome Damage Signals in the Activation of LRRK2 |
| Suzanne R. Pfeffer, Stanford University Short Talk: Parkinson’s-Linked Mutations Converge on a Neuroprotective Ciliogenesis Pathway in the Brain |
| 7:00–8:00 PM | Social Hour with Lite Bites | Sea to Sky A |
| 7:30–10:00 PM | Poster Session 2 | Sea to Sky A |
| 7:00–8:00 AM | Breakfast | Sea to Sky A |
| 8:00–11:00 AM | Therapeutics based in Genetics and Cellular Pathways | Sea to Sky C |
| * Soojin Kim, Genentech Session Chair |
| Timothy A. Ryan, Weill Medical College of Cornell University Dysregulation of Central Metabolism Pathways in Parkinson’s Disease and New Therapeutic Strategies |
| Sarah DeVos, Curie.Bio Transporting Different Drug Modalities Across the BBB Using Transferrin Receptor |
| Matthew Nolan, Massachusetts General Hospital Short Talk: Inhibition of Geranylgeranylation Restores Stathmin-2 Expression in TDP-43 Deficient Cells and Promotes Neurite Outgrowth |
| Timothy J Hines, The Jackson Laboratory Short Talk: ATF4 Mediates Neuromuscular Deficits in CMT2D Mice |
| Tanya N Weerakkody, Denali Therapeutics Short Talk: PILRA Regulates Microglial Immunometabolism to Reduce Disease Pathology as a Candidate Therapeutic Target for Alzheimer’s Disease |
| Rajeev Sivasankaran, Voyager Therapeutics Short Talk: Intravenous Delivery of VY1706, a CNS Penetrant AAV Gene Therapy for Alzheimer’s Disease, Provides Broad Tau Lowering in Mouse Models of Tauoapathy and NHPs |
| Leonard Petrucelli, Mayo Clinic Jacksonville Short Talk: HDGFL2 Cryptic Peptide as a Biomarker for TDP-43 Proteinopathies |
| Alessandro Moro, VectorY BV Short Talk: AAV-Mediated Therapy of an Intrabody Targeting TDP-43 for Amyotrophic Lateral Sclerosis |
| 9:00–9:20 AM | Coffee Break | Grand Foyer |
| 11:00–2:30 PM | On Own for Lunch |
| 2:30–4:30 PM | Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions | Sea to Sky C |
| * Sarah DeVos, Curie.Bio Session Chair |
| Sandrine Da Cruz, VIB-KU Leuven Local Mechanisms of Axonal/Synaptic Maintenance and Demise in ALS/FTD |
| Sarah E Heuer, Brigham and Women's Hospital Dissecting Alzheimer’s Disease Genetic Risk Using Stem Cell Models: ABCA7 Deficiency Disrupts Lysosomal Function and Alters Inflammatory Responses in Microglia |
| Amanda McQuade, UCSF Transcriptional And Epigenetic Control Of Disease-Relevant Microglial Activation States |
| Jeffrey D. Rothstein, Johns Hopkins University Whole Genome Screen-Based Identification and Examination of Novel Genes for Regulation of TDP-43 Import in Alzheimer’s Disease, Sporadic and C9orf72 ALS/FTD |
| Daichi Shonai, Duke university Discovery of Prodromal α-Synuclein Suppressors via Dopaminergic Neuron Proteomics and CRISPR Survival Screening |
| Martine Therrien, University of California Davis Using Xenograft Model to Identify How Genetics Impact Microglial Response to Peripheral Inflammation |
| Roi Meir, The Hebrew University of Jerusalem Early Neuronal Reprogramming and Cell Cycle Re-entry Shape the Alzheimer’s Disease Cascade |
| Shannon L Macauley, University of Kentucky Targeting Metabolic Inflexibility to Restore Slow Wave Sleep in Alzheimer’s Disease |
| 4:30–5:00 PM | Coffee Available | Grand Foyer |
| 5:00–6:45 PM | Transformative New Technologies in Molecular and Cellular Neuroscience and Disease | Sea to Sky C |
| * Carlo Condello, University of California, San Francisco Session Chair |
| Roberto Zoncu, University of California, Berkeley Decoding Cholesterol-mTORC1 Signaling in Organelle Homeostasis and Neurodegeneration |
| Andrew Bassett, Wellcome Sanger Institute Massively Parallel Profiling of Neuronal and Glial Perturbation States |
| Michael Ward, NIH Leveraging iPSC Models and ‘Omics to Study Neurodegeneration |
| Ophir Shalem, University of Pennsylvania Short Talk: Towards Pooled Optical Profiling of Proteome Organization in Cell Lines and Neurons |
| 6:45–7:00 PM | Meeting Wrap-Up: Outcomes and Future Directions (Organizers) | Sea to Sky C |
| 7:00–8:00 PM | Social Hour with Lite Bites | Sea to Sky A |
| 8:00–9:00 PM | Entertainment | Sea to Sky C |
| 12:00–11:59 PM | Departure |